This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is supporting research to identify the key factors that determine individual response to transcranial direct current stimulation (tDCS). The $498,429 award to the Children's Research Institute will apply advanced machine learning algorithms to a multi-modal dataset that includes structural MRI, functional MRI, cognitive performance, and other measures...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants, aims to investigate the efficacy of maintenance repetitive transcranial magnetic stimulation (rTMS) as a treatment for individuals with treatment-resistant depression (TRD). The $968,769 award will support a two-phase study across three research sites - the University of California San Diego, Cornell University, and Australian National...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $777,016 to The Mclean Hospital Corporation to study the synaptic mechanisms of continuous theta burst stimulation (cTBS) in the treatment of depression. The 5-year project aims to elucidate the specific neurological mechanisms by which cTBS, a form of repetitive transcranial magnetic stimulation (rTMS), can reduce cortical excitability in...
The National Institute of Mental Health (NIMH) awarded a $156,500 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Emory University to identify patients with true treatment failure for major depressive disorder (MDD) who may benefit from earlier referral to alternative treatments like transcranial magnetic stimulation, ketamine, and vagus nerve stimulation. The project aims to use trajectory classification methods to empirically separate partial response from true...
This $223,176 Project Grant, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to assess the effects of transcranial electrical stimulation on audiovisual integration and hallucinations. The project aims to use electroencephalography (EEG) and clinical measures to evaluate whether cathodal high-definition transcranial direct current stimulation (HD-tDCS) to the right superior temporal sulcus can...
This Project Grant award of $784,096.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to develop optimized methods for measuring brain excitability in depression. The key objectives are to: Investigate how adjusting transcranial magnetic stimulation (TMS) parameters affects neural activity measured with intracranial EEG. Optimize the TARGE"T" system to enhance short-latency TMS-evoked potentials...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $638,872 to The Feinstein Institutes for Medical Research to conduct research on "Elucidating Reward Network Modulation in Medial Forebrain Bundle Deep Brain Stimulation for Treatment Resistant Depression". The goal is to use brain imaging to understand how deep brain stimulation of the medial forebrain bundle impacts the brain's reward processing...
This federal Project Grant award of $176,979 from the National Institute of Mental Health (NIMH) under CFDA program 93.242 - Mental Health Research Grants supports research to develop personalized neuromodulation approaches to target dysregulated motivational responses underlying social avoidance behavior in patients with major depressive disorder (MDD) or social anxiety disorder (SAD). The key objectives are to use transcranial magnetic stimulation (TMS) to causally modulate patient-specific...
The National Institute of Mental Health (NIMH) awarded a $197,576 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to the University of California, San Diego (UCSD) for the project "Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression (COMBAT-SI)". The project aims to investigate cortical inhibition as a biological target of...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding a research project to elucidate the glutamatergic mechanisms by which repetitive transcranial magnetic stimulation (rTMS) exerts its antidepressant effects. The $198,728 award, effective February 11, 2025, supports the use of cutting-edge ultra-high field (7T) neuroimaging techniques, including glutamate chemical exchange saturation transfer...