This $1,711,908 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 5-year study at the University of California, San Francisco (UCSF) to evaluate the association between depressive symptoms, cortico-limbic tau deposition, and cognitive decline in individuals with mild cognitive impairment (MCI). The goals are to: 1) assess the relationship between depressive symptoms and tau in the brain, 2) clarify how tau, brain volume, amyloid-beta, cerebral blood flow, and white matter hyperintensities relate to cognition in MCI, and 3) evaluate how baseline tau and other neurobiological factors predict cognitive decline and depressive symptom progression over 30 months. The study will enroll 110 MCI participants with chronic late-life major depression and obtain measures of tau, amyloid-beta, brain volume, cerebral blood flow, and white matter changes using advanced neuroimaging techniques. Data from 330 additional MCI participants will be obtained from the Alzheimer's Disease Neuroimaging Initiative for comparative analyses. The findings are intended to clarify the neurobiological mechanisms linking depressive symptoms to cognitive dysfunction and dementia risk in older adults.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.7m | 4/8/25 |