Project Grant R01MH139831
- The National Institute of Mental Health awarded Biosignal Solutions LLC $453,695 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate BrainGain, a mobile neurofeedback platform designed to improve working memory in individuals with schizophrenia. BrainGain translates laboratory-based electroencephalographic neurofeedback (EEG-NFB) technology into a home-use mobile platform consisting of a smartphone application and wireless EEG headband. The...
- The National Institute of Mental Health awarded the University of Pittsburgh $569,831 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate cortical circuit abnormalities underlying deficits in visual and prefrontal gamma oscillations in schizophrenia. The award funds research combining high-resolution expansion microscopy with multiscale computational modeling to evaluate synaptic mechanisms that disrupt gamma oscillations in schizophrenia. The...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $3.084 million on June 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop decoded functional magnetic resonance imaging neurofeedback as a novel treatment for auditory verbal hallucinations in schizophrenia. The project will test decoded neurofeedback, an fMRI-based technique that enables individuals to modify brain activation patterns in real time through...
- The National Institute of Mental Health awarded the University of California, Los Angeles $817,686 under the Mental Health Research Grants program (CFDA 93.242) on April 25, 2026, to investigate autonomic regulation of brain function and cognition in patients with first-episode schizophrenia and healthy individuals. The project examines how dysfunction in the autonomic nervous system mechanistically contributes to disorganized brain activity and cognitive impairment in schizophrenia, focusing on...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $433,125 Project Grant to the University of California, Los Angeles (UCLA) under the Mental Health Research Grants program (CFDA 93.242) for the period September 1, 2025 through August 31, 2027. This research project investigates inter-brain synchrony as a neural mechanism underlying social connection deficits in schizophrenia—a core symptom of the disorder that current treatments fail to address. The study will...
- The National Institute of Mental Health, part of the Department of Health and Human Services, awarded the University of California, San Diego $684,740 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurocognitive mechanisms underlying fear extinction learning and to test whether computer-based working memory training enhances exposure-based treatment for anxiety disorders. The research will examine whether working memory training administered...
- The National Institute of Mental Health awarded $191,910 to the University of Manitoba on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize neural abnormalities associated with aberrant predictive learning in schizophrenia and their relationships with specific illness features over time. The recipient will conduct an electroencephalography (EEG) study of auditory predictive learning using a Bayesian computational framework. The study enrolls 90 adults...
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco $800,384 on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct molecular and functional dissection of prefrontal-hippocampal long-range inhibition. The project investigates a novel long-range GABAergic pathway from prefrontal cortex to hippocampus that mediates top-down control of hippocampal function. The research will elucidate mechanisms through...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $128,000.00 to the Boston VA Research Institute, Inc. to investigate the spectral components of abnormal spontaneous gamma activity in schizophrenia and translational mouse models. The research aims to better understand the neural mechanisms underlying spontaneous gamma activity, which has been used as an index of excitation-inhibition...
- The National Institute of Mental Health awarded the University of California, Los Angeles $444,845 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, to conduct a two-year study examining intra-individual determinants of neural oscillation phenomena. The funded research deploys multi-sensor measurements to concurrently capture objective measures of arousal (heart rate, heart rate variability, galvanic skin response, pupil metrics), motor activation (body, limb,...
The National Institute of Mental Health awarded the University of California, San Diego $1,553,622 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a confirmatory efficacy trial of gamma EEG-neurofeedback treatment targeting working memory deficits in individuals with schizophrenia. The award funds a randomized clinical trial designed to confirm efficacy of a neuromodulation intervention that uses real-time EEG neurofeedback to increase synchronous activation of frontal gamma waves (30–45 Hz oscillations). The trial builds on prior proof-of-concept and preliminary efficacy studies demonstrating that frontal gamma synchrony correlates with working memory performance in healthy adults and is impaired in schizophrenia. The intervention delivers visual or auditory feedback to enable individuals to self-modify brain activity, targeting the frontal cortex neural circuit supporting working memory as a non-pharmacologic alternative to antipsychotic medications, which show limited efficacy on cognitive domains. The recipient, UC San Diego, will conduct the work at La Jolla, California. The period of performance extends from August 1, 2026, through April 30, 2030. The assistance type is a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/24/26 | ||
| Not listed | $776.8k | 7/30/26 |