Project Grant R21MH143362
- The National Institute of Mental Health awarded the University of California, Los Angeles $817,686 under the Mental Health Research Grants program (CFDA 93.242) on April 25, 2026, to investigate autonomic regulation of brain function and cognition in patients with first-episode schizophrenia and healthy individuals. The project examines how dysfunction in the autonomic nervous system mechanistically contributes to disorganized brain activity and cognitive impairment in schizophrenia, focusing on...
- The National Institute of Mental Health awarded the University of Southern California $751,034 on August 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a neuroscience research project examining how the brain processes uncertainty in noisy, dynamically changing environments. The project, titled "Unraveling Neural Mechanisms Underlying Learning in a Noisy, Dynamically Changing World," investigates computational and neural mechanisms by which the brain...
- The National Institute of Mental Health awarded the University of California, Los Angeles $118,404 under the Mental Health Research Grants program (CFDA 93.242) on July 1, 2026, to support research examining dynamic functional network biomarkers of emotion regulation flexibility in internalizing disorders. The research addresses transdiagnostic biomarkers for internalizing disorders including depression, anxiety, and posttraumatic stress. The recipient will analyze a large-scale longitudinal...
- The National Institute of Mental Health awarded California Institute of Technology $1,417,650 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop instrumentation for synchronized multimodal recording and analysis of human behavior and neural activity during complex, unstructured tasks. The project develops a system to acquire and synchronize behavioral data streams including head-mounted eye tracking to monitor gaze position, egocentric and...
- The National Institute of Mental Health awarded the University of California, Los Angeles $772,569 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct highly parallel analysis of high-confidence autism spectrum disorder and schizophrenia risk gene mechanisms. The recipient will study approximately 50 risk genes identified as harboring rare, protein-disrupting heterozygous mutations associated with these neuropsychiatric disorders. The work leverages a...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $433,125 Project Grant to the University of California, Los Angeles (UCLA) under the Mental Health Research Grants program (CFDA 93.242) for the period September 1, 2025 through August 31, 2027. This research project investigates inter-brain synchrony as a neural mechanism underlying social connection deficits in schizophrenia—a core symptom of the disorder that current treatments fail to address. The study will...
- The National Institute of Mental Health awarded the University of California, Los Angeles $180,670 on October 25, 2025, under the Mental Health Research Grants program (CFDA 93.242) to conduct research on the neuronal correlates of avoidance and pursuit during human ambulatory navigation. The project investigates how the medial temporal lobe, including the hippocampus and amygdala, supports simultaneous reward-seeking and risk-aversion during naturalistic navigation in freely-moving humans. UCLA...
- The National Institute of Mental Health awarded the University of California, Los Angeles $424,433 on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a framework and online implementation tool for participant engagement in brain-computer interface early feasibility studies. The project addresses a critical gap in BCI research: while participant engagement is recognized as valuable in other clinical domains, BCI early feasibility studies—where people with...
- The National Institute of Mental Health awarded Yale University $847,792 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop integrated human thalamocortical assembloids that produce thalamocortical oscillations—brain rhythms representing inner states of the brain for vigilance and behavior. The project addresses the lack of tractable models for investigating human brain rhythm mechanisms, which are dysregulated in most neuropsychiatric and neurodegenerative...
- The National Institute of Mental Health awarded University of California, Los Angeles $764,785 under the Mental Health Research Grants program (CFDA 93.242) on July 16, 2026, to investigate context-dependent disease mechanisms in neurodevelopmental disorders, specifically the 16p11.2 chromosomal deletion (16PDEL) implicated in autism, intellectual disability, and ADHD. The project will use a proprietary in vitro human stem cell platform called the Cell Village to conduct high-throughput...
The National Institute of Mental Health awarded the University of California, Los Angeles $444,845 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, to conduct a two-year study examining intra-individual determinants of neural oscillation phenomena. The funded research deploys multi-sensor measurements to concurrently capture objective measures of arousal (heart rate, heart rate variability, galvanic skin response, pupil metrics), motor activation (body, limb, and head displacement and variability), and neural oscillations. Data collection occurs repeatedly in the same individuals over six months to capture within-subject variation corresponding to system interactions. The project aims to identify the role of motor and arousal system contributions to variability in neural oscillations (theta-beta ratio, alpha power, and spectral slope) and to determine the role of motor and arousal signals in predicting behavioral outcomes from neural oscillations. Results will inform whether reconsideration is warranted of dominant interpretations of neural oscillations in attention-deficit/hyperactivity disorder and will model an approach to addressing individual variability questions through within-subject designs nested in a precision-neuroscience framework. Work is performed at UCLA in Los Angeles, California. The period of performance runs from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.8k | 9/1/26 |