Project Grant R43MH142174
- The National Institute of Mental Health awarded the University of California, San Diego $1,553,622 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a confirmatory efficacy trial of gamma EEG-neurofeedback treatment targeting working memory deficits in individuals with schizophrenia. The award funds a randomized clinical trial designed to confirm efficacy of a neuromodulation intervention that uses real-time EEG neurofeedback to increase synchronous...
- The National Institute of Mental Health awarded Openbci, Inc. $732,736 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop Cyton V2, an affordable, FDA-cleared bioamplifier system with open-source hardware and software for clinical-grade EEG and multimodal physiological monitoring. Openbci will design, manufacture, and obtain FDA clearance for a medical-grade, adaptable, and repairable bioamplifier system intended to address cost barriers that limit...
- The National Institute on Aging awarded Advanced Brain Monitoring, Inc., a veteran-owned small business, $690,899 on September 16, 2025, under the Aging Research program (CFDA 93.866) to validate and deploy a mobile electroencephalography platform for objective assessment of neurocognitive deficits in post-acute sequelae of COVID-19. Advanced Brain Monitoring will conduct a longitudinal study over one year (through May 31, 2027) enrolling 52 participants with neurological manifestations of...
- The National Institute on Aging awarded Oscilloscape, Inc. $1,402,614 on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop and test a wearable digital health device delivering music-based and synchronized visual brain stimulation therapy for adults with Alzheimer's disease and mild cognitive impairment. The device, called SYNG (SynchronyGamma), uses patented neural network technology to model and stimulate healthy brain rhythms through neural entrainment. Prototype...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $3.084 million on June 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop decoded functional magnetic resonance imaging neurofeedback as a novel treatment for auditory verbal hallucinations in schizophrenia. The project will test decoded neurofeedback, an fMRI-based technique that enables individuals to modify brain activation patterns in real time through...
- The National Institute of Mental Health awarded Ampa Inc. $3.168 million on September 15, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a next-generation transcranial magnetic stimulation (TMS) system for scalable, personalized depression treatment. Ampa is engineering a portable TMS device that replicates the efficacy of Stanford Neuromodulation Therapy (SNT)—which achieves approximately 80 percent symptom remission in five treatment days—without...
- The National Institute of Mental Health awarded the University of California, Los Angeles $424,433 on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a framework and online implementation tool for participant engagement in brain-computer interface early feasibility studies. The project addresses a critical gap in BCI research: while participant engagement is recognized as valuable in other clinical domains, BCI early feasibility studies—where people with...
- The National Institute of Mental Health awarded Miresource, Inc. $1.744 million on September 12, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop a longitudinal mental health monitoring platform that generates personalized care guides and treatment referrals. Miresource will integrate software solutions, curate mental health content, and employ artificial intelligence to create personalized guides and automate triage and referral recommendations. The project aims to...
- The National Institute of Mental Health awarded California Institute of Technology $1,417,650 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop instrumentation for synchronized multimodal recording and analysis of human behavior and neural activity during complex, unstructured tasks. The project develops a system to acquire and synchronize behavioral data streams including head-mounted eye tracking to monitor gaze position, egocentric and...
- The National Institute of Mental Health awarded The Johns Hopkins University $538,657 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop Neural Navigator, a standardized platform for quantifying circuit pathophysiology in patient-derived cerebral organoids using multi-electrode array recordings and machine learning-based modeling to decode psychiatric disorder signatures in schizophrenia and bipolar disorder. The project aims to establish reproducible...
The National Institute of Mental Health awarded Biosignal Solutions LLC $453,695 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate BrainGain, a mobile neurofeedback platform designed to improve working memory in individuals with schizophrenia. BrainGain translates laboratory-based electroencephalographic neurofeedback (EEG-NFB) technology into a home-use mobile platform consisting of a smartphone application and wireless EEG headband. The platform guides users to enhance frontal gamma brain wave activity—associated with improved working memory—through visual and auditory feedback typically presented as a game interface. The recipient will conduct user-centered co-design workshops with patients, caregivers, and healthcare staff to simplify headsets currently used in clinical trials for home and community clinic use. Biosignal Solutions will validate the mobile platform through equivalency testing against existing in-laboratory gamma-NFB protocols at UC San Diego to confirm reliable signal acquisition, preprocessing, and neurofeedback training outcomes. Performance occurs in La Jolla, California. The period of performance runs from August 1, 2026, through July 31, 2028. This is a Phase I Small Business Innovation Research project.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $453.7k | 7/23/26 |