Project Grant R01MH140884
- The National Institute of Mental Health awarded the University of Pittsburgh $158,960 on January 21, 2027, under the Mental Health Research Grants program (CFDA 93.242) to investigate inhibitory control of dendritic spikes in hippocampal CA1 pyramidal neurons. The project will use optogenetics, two-photon calcium imaging, and voltage imaging to explore how dendrite-targeting somatostatin interneurons regulate dendritic spike dynamics, specifically examining how synaptic inhibition modifies...
- The National Institute of Mental Health awarded the University of California, San Diego $1,553,622 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a confirmatory efficacy trial of gamma EEG-neurofeedback treatment targeting working memory deficits in individuals with schizophrenia. The award funds a randomized clinical trial designed to confirm efficacy of a neuromodulation intervention that uses real-time EEG neurofeedback to increase synchronous...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $128,000.00 to the Boston VA Research Institute, Inc. to investigate the spectral components of abnormal spontaneous gamma activity in schizophrenia and translational mouse models. The research aims to better understand the neural mechanisms underlying spontaneous gamma activity, which has been used as an index of excitation-inhibition...
- The National Institute of Mental Health awarded the University of Pittsburgh $739,727 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop federated statistical harmonization and multivariate modeling frameworks for investigating altered brain aging patterns in individuals with severe mental illness and the modifying effects of metabolic syndrome. The project addresses methodological challenges in large-scale neuroimaging research by leveraging the ENIGMA...
- The National Institute of Mental Health awarded the University of Pittsburgh $1,004,971 through the Mental Health Research Grants program (CFDA 93.242) on April 8, 2026, to develop a platform for measuring and analyzing brain activity, cognitive states, behavior, and physiology during multiday neural recordings in individuals undergoing surgical treatment for epilepsy. The project will integrate wearable technology and artificial intelligence for behavioral and physiological monitoring alongside...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Rochester a $423,500 Project Grant under the Mental Health Research Grants program (CFDA 93.242) on May 5, 2025, with a completion date of May 4, 2027. This award supports research investigating visual perception and predictive processing dysfunction in schizophrenia and related psychiatric disorders. The research employs high-density electroencephalography (EEG) and innovative visual...
- The National Institute of Mental Health awarded the University of Pittsburgh $437,250 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate parvalbumin interneuron diversity and plasticity in primary visual and prefrontal cortical areas. The award funds a two-year exploratory research project running through March 31, 2028, conducted in Pittsburgh, Pennsylvania. The research uses patch-seq methodology to integrate single-cell RNA sequencing,...
- The National Institute of Mental Health awarded the University of Illinois $440,908 on July 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating the roles of the prefrontal cortex and ventral hippocampus during adolescence in the maturation of social and cognitive behaviors. The research examines how changes in GABAergic inhibitory transmission in these limbic structures contribute to the refinement of higher cognitive functions and social...
- The National Institute of Mental Health awarded the University of Southern California $249,000 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support basic research on the dysbindin-1–SRC–GluN2A pathway as a mechanism to restore glutamate receptor function in schizophrenia. The research employs a cell-circuit-behavior approach to assess how dysbindin-1 and SRC regulate N-methyl-D-aspartate receptor (NMDAR) signaling and working memory. The study will measure...
- The National Institute of Mental Health awarded The Johns Hopkins University $807,893 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct advanced magnetic resonance imaging research on neurovascular abnormalities in individuals with schizophrenia across the life span. The recipient will perform quantitative MR imaging at 7 Tesla field strength to test the hypothesis that cerebral microvasculature and cerebrospinal fluid circulation and clearance...
The National Institute of Mental Health awarded the University of Pittsburgh $569,831 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate cortical circuit abnormalities underlying deficits in visual and prefrontal gamma oscillations in schizophrenia. The award funds research combining high-resolution expansion microscopy with multiscale computational modeling to evaluate synaptic mechanisms that disrupt gamma oscillations in schizophrenia. The project examines how deficits in excitatory-inhibitory synaptic transmission between pyramidal neurons and parvalbumin-expressing interneurons generate lower gamma-oscillation power in both primary visual cortex and prefrontal cortex, impairing stimulus encoding and working memory maintenance. The research posits a disease model in which shared synaptic deficits display region-specific severity and produce gamma oscillations with distinct temporal dynamics—transient oscillations in sensory cortex and sustained oscillations in prefrontal cortex—with sustained oscillations more vulnerable to synaptic disruption. The award obligated $569,831 for the period September 1, 2026, through May 31, 2031. Work is performed at the University of Pittsburgh, Pittsburgh, Pennsylvania. This is assistance funding classified as a Project Grant, supporting investigator-initiated basic research in neuroscience under NIMH's mission to advance prevention, recovery, and cure of mental illness through research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $569.8k | 9/1/26 |