This is a Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) for the project titled "EARLY LIFE STRESS AND DIFFERENTIAL EFFECTS ON THE MOLECULAR MATURATION OF SPECIFIC SUBTYPES OF BRAIN SEROTONIN NEURONS". The $466,125 grant was awarded on August 25, 2023 to President And Fellows Of Harvard College, acting through the Harvard Medical School Division, to investigate the impact of early life stress and...
This $1.8 million project grant from the National Institutes of Health's National Institute of Mental Health will fund the development of high-throughput methods for measuring synaptic connectivity at single-cell resolution in the cerebral cortex. Over a three-year period from September 2022 through August 2025, The Broad Institute, Inc. will pursue viral, functional, and molecular approaches to map local cortical circuitry. These include optimizing rabies-based trans-synaptic tracing for...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research to investigate the role of the serotonergic system in altering social behavior following early life adversity. The $444,125 award to George Washington University will fund a 2-year study using electrophysiology, behavioral assays, and fiber photometry to examine how early life stress impacts the excitability of serotonergic neurons and...
The National Institute of Mental Health (NIMH) awarded a $711,897 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Leland Stanford Junior University (Stanford University) to study the serotonergic modulation of aggressive and prosocial behaviors. The 5-year research project, commencing on December 1, 2024, aims to characterize the temporal dynamics, cellular targets, and contextual influences of serotonin's effects on aggression and prosocial behavior in mice. Key objectives...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $114,899 to Brown University to investigate the neurocomputational mechanisms by which serotonin, sustained stress, and cognitive control influence mental effort allocation. The project aims to leverage computational modeling, psychopharmacology, and fMRI to understand how the controllability of sustained stressors drives different mental effort...
This $254,250 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to characterize a specialized serotonergic-septohippocampal brain circuit and its role in modulating context-triggered drug-seeking behavior and relapse vulnerability. The research will be conducted by President and Fellows of Harvard College, doing business as Harvard Medical School, from July 2024 through June 2026. Specifically, the grant...
This $2,220,017.04 Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports a large-scale, single-cell investigation of the molecular and cellular networks underlying mood regulation circuitry in major depressive disorder (MDD). The key objectives are to: 1) Identify transcriptomic changes associated with MDD at the single-cell level across three brain regions (anterior cingulate cortex, basolateral...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....
This Cooperative Agreement award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting a $803,786 project titled "BRAIN CONNECTS: HIGH-THROUGHPUT SINGLE CELL PROJECTION MAPPING AND SPINE QUANTIFICATION IN THE PRIMATE BRAIN BY SYNAPTIC BARCODING." The project, led by the Broad Institute of MIT and Harvard, aims to develop innovative technologies to systematically map the projections of thousands of midbrain...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will support research to map the functional G protein-coupled receptor (GPCR) diversity in neurons and investigate the spatiotemporal signaling consequences. The $597,844 award, effective September 1, 2024 through March 31, 2027, will be provided to the Regents of the...