Project Grant DP2MH132942

Award Date 9/1/22
Completion Date 8/31/25
Dollars Obligated $1.8M
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....
The U.S. National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,860,153 Cooperative Agreement grant to The Regents of the University of California, San Francisco (UCSF) under the NIBIB's "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program. The key objectives of this 3-year project, starting August 2024, are to establish scalable tools that combine spatial transcriptomics and connectomics methods to...
This $21.4 million cooperative agreement from the National Institute of Mental Health will fund research to identify gene regulatory elements that can target and manipulate specific neuronal cell types and brain circuits across species, including in human organoids. Awarded on September 1, 2022 to the Broad Institute, Inc. with completion by August 31, 2025, the funding supports the Mental Health Research Grants program. The Broad Institute and collaborators at Harvard University will profile...
The National Institutes of Health (NIH) awarded a $1,385,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute, a non-profit research organization, to develop novel techniques for measuring the input-output operations of individual neurons in the mouse cortex. The project aims to overcome challenges in understanding how neurons in the mammalian brain transform their synaptic inputs into outputs, which is critical for designing effective brain-machine...
This Cooperative Agreement award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to enable systematic mapping of presynaptic and postsynaptic neural connectivity in the primate brain. The $803,786 award will support the development of innovative technologies to: 1) deliver barcoded RNAs to presynaptic and postsynaptic sites using adeno-associated viruses (AAVs) for high-throughput single-cell projection mapping, and 2)...
The National Institute of Mental Health awarded Oregon Health & Science University a $4,214,208 project grant under the Mental Health Research Grants program (CFDA 93.242) for the period of August 1, 2022 through July 31, 2025. The grant funds development of a new technique called SLIDE-SBARRO to generate quantitative models of synaptic networks in mouse striatum through spatially-resolved single-cell RNA sequencing of hundreds of thousands of cells. The aims are to create an...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $4,101,949 to The Leland Stanford Junior University to develop innovative neuroscience tools for precisely manipulating synaptic connections between genetically- or anatomically-defined neuronal populations. The project aims to engineer three different tool platforms that enable drug-controlled, trans-synaptic manipulation of neuronal...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $749,331 to the University of Southern California to develop new methods for anterograde tracing of active neural circuits. The key objectives are: Developing a method for anterograde tracing from inhibitory neurons that is monosynaptic, activity-dependent, and non-toxic, allowing genetic labeling and access to postsynaptic cells. This...
This $414,650 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the molecular mechanisms regulating the maturation of silent synapses in the brain's excitatory neural networks. The primary awardee, the University of Pittsburgh, will employ genetic manipulations, electrophysiology, quantitative proteomics, and imaging techniques to elucidate the signaling pathways that control...
The University of Texas Health Science Center at Houston was awarded $603,872 under the National Institute of Mental Health's Mental Health Research Grants program to develop tools and methods to map electrical synaptic connectivity in neural networks. The three-year project grant aims to image gap junction connectivity in electron microscopy datasets, estimate the size, strength, and plasticity of gap junctions, and determine coupling conductance through electrophysiological and modeling...

This $1.8 million project grant from the National Institutes of Health's National Institute of Mental Health will fund the development of high-throughput methods for measuring synaptic connectivity at single-cell resolution in the cerebral cortex. Over a three-year period from September 2022 through August 2025, The Broad Institute, Inc. will pursue viral, functional, and molecular approaches to map local cortical circuitry. These include optimizing rabies-based trans-synaptic tracing for neuronal classification via multiplexed fluorescent in situ hybridization, combining holographic optogenetic stimulation with multiplexed patch-clamp recording to probe more synaptic connections per animal, and designing molecular barcodes for pre- and post-synaptic sites detectable by the same method along with transcriptional cell-typing information. The work aims to provide insight into pathophysiological mechanisms of schizophrenia and bipolar disorder by applying these new connectivity analysis techniques to high-confidence risk genes for the disorders.

Generated 1/6/24, 10:34 AM