This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $444,125 to George Washington University to investigate the role of serotonergic neurons in alterations to adult social behavior following early life adversity. The 2-year project, running from May 1, 2025 to April 30, 2027, will use electrophysiology, behavioral assays, and fiber photometry to study the impact of modulating serotonergic neuron...
This federal Project Grant award of $592,831, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to understand the neural circuit mechanisms linking early life trauma to impulsive aggression. The primary goal is to characterize the role of the thalamic nucleus reuniens (RE) and its projections to the ventral hippocampus in mediating the maladaptive effects of early life trauma on aggressive behaviors. The...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $185,625.00 to study the neural mechanisms underlying socially transmitted aggression in mice. The research aims to investigate how familiarity between mice influences the activation and plasticity of the medial amygdala (MEAPV) to ventromedial hypothalamus (VMHVL) pathway, which is hypothesized to drive socially learned aggressive behaviors. The...
This Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) provides $727,895 to the Trustees of Indiana University, doing business as Indiana University, to conduct research on the alternative neuroendocrine mechanisms regulating aggression. The 5-year project aims to investigate how the pineal hormone melatonin orchestrates increased aggressive behavior in males and females through actions on adrenal DHEA, its conversion to bioactive...
The National Institute of Mental Health (NIMH) awarded a $1,401,862 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to the University of California, Berkeley. The 5-year grant, which commenced on September 21, 2024, will support research to investigate the role of the orbitofrontal cortex (OFC) in inhibiting habitual responses in the striatum to enable goal-directed decision-making. The researchers will use a novel behavioral task and advanced neural recording...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $375,927 to the Rector & Visitors of the University of Virginia (UVA) to conduct research on the impact of premature birth and serotonin signaling on the development of the prefrontal cortex. The research aims to mechanistically determine how the timing of birth and serotonin levels affect intrinsic neural activity and the establishment of...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $816,063 to The Trustees of Columbia University in the City of New York to conduct research on the neural mechanisms underlying how social stimuli elicit motivated behavior. The key focus of the research is to understand how neural representations of social rank information, such as dominant and submissive social cues, converge onto brain...
This $106,668 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research investigating the role of the medial orbitofrontal cortex (MOFC) in negative reinforcement learning. The project aims to monitor and manipulate MOFC neuron activity in mice as they learn a novel negative reinforcement task, in order to better understand the cellular and circuit-level mechanisms involved in this type of learning. The...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $752,854 to Pennsylvania State University to study neural markers of aggression and irritability in youth with ADHD and their potential to predict treatment response to CNS stimulant medication. The key products and services to be delivered include: 1) Examining the capacity of event-related potentials (ERPs) associated with reinforcement...
This is a Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) for the project titled "EARLY LIFE STRESS AND DIFFERENTIAL EFFECTS ON THE MOLECULAR MATURATION OF SPECIFIC SUBTYPES OF BRAIN SEROTONIN NEURONS". The $466,125 grant was awarded on August 25, 2023 to President And Fellows Of Harvard College, acting through the Harvard Medical School Division, to investigate the impact of early life stress and...