Project Grant R01MH134978
Award Date
7/15/24
Completion Date
1/31/29
Dollars Obligated
$1.1M
Federal Agency
National Institute of Mental Health
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Washington, DC, USA
Similar Awards
The National Institute of Mental Health (NIMH) awarded a $692,043 Project Grant (CFDA 93.242) to The Regents of the University of California, San Francisco (UCSF) to study the role of presynaptic homeostatic plasticity in mental health disorders, including autism and intellectual disability. The research aims to establish a mechanistic framework linking homeostatic plasticity to the genetic underpinnings of these disorders, with the goal of informing future therapeutic approaches. The funding...
Northwestern University received a $420,790 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) on September 15, 2023. The funding will support a research project titled "Deep Mutational Scanning of CHD2 for Variant Interpretation in Neurodevelopmental Disorders". This effort aims to develop a high-throughput assay to evaluate the functional...
The National Institute of Mental Health (NIMH) awarded a $1,526,424 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Texas Southwestern Medical Center to conduct research on the impact of DNA supercoiling and topoisomerases on neuronal activity-dependent chromatin organization. The project aims to: 1) map the distribution of underwound (negatively supercoiled) DNA in mouse cortical neurons and assess how activity-driven supercoiling distributes within the...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $1,879,407 to the Regents of the University of Michigan to study the roles of histone H3K4 methylation enzymes in synaptic scaling and neural plasticity. The goal is to determine how this family of chromatin regulatory enzymes contributes to the balance of neural network excitability, which is critical for cognitive function. The research will 1)...
This National Institute of Mental Health (NIMH) Project Grant award under the Mental Health Research Grants program (CFDA 93.242) provides $237,750 to the University of California, Merced to elucidate the neurodevelopmental functions of the SMARCC2 gene and the Brahma Associated Factor (BAF) chromatin remodeling complex. The central hypothesis is that the neuronal BAF (nBAF) complex, which includes the SMARCC2 subunit, drives RNA Polymerase 2 elongation and synapse maturation via intrinsically...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research into the role of ectopic germline gene expression in neurodevelopmental disorders. The $234,000 award to the Regents of the University of Michigan will investigate whether the aberrant expression of germline-specific genes contributes to the neurological complications observed in a mouse model lacking the chromatin regulator KDM5C....
The National Institute of Mental Health (NIMH) awarded a $1,380,070 Project Grant (CFDA 93.242) to Duke University to conduct research exploring the cellular properties and circuit functional roles of human cortical interneurons. The 3-year grant, which runs from September 2024 to September 2027, will utilize live brain specimens and a novel genetic tool to investigate the diversity, circuit functions, and pathophysiologies of human interneuron populations. This research aims to advance the...
The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Research Foundation For Mental Hygiene, Inc. (RFMH), doing business as the New York Psychiatric Center. The $182,993 grant, awarded on September 1, 2024, will support a 4-year research project to study the role of acetylcholine (ACh) release in the dorsomedial striatum (DMS) during reversal learning, a form of cognitive flexibility impaired in psychiatric...
This $3,498,931 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a comprehensive study titled "Cross Scale Interrogation of NPD Genes (SING) in Mice." The primary aim is to investigate the biological pathways and neural circuit changes caused by the loss of 100 neurodevelopmental and psychiatric disorder (NPD) genes in mice. The research team at Pennsylvania State University, including the...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA on September 5, 2024. The $911,929 grant will fund a 5-year research project to combine in vivo genetic screening with spatial mapping of brain cell types to study the mechanisms by which genetic variants associated with autism spectrum disorder (ASD) and neurodevelopmental delay lead to these conditions. The project will adapt...