Project Grant R21MH135290

Award Date 7/1/24
Completion Date 6/30/25
Dollars Obligated $234K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Michigan, USA
Similar Awards
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $1,879,407 to the Regents of the University of Michigan to study the roles of histone H3K4 methylation enzymes in synaptic scaling and neural plasticity. The goal is to determine how this family of chromatin regulatory enzymes contributes to the balance of neural network excitability, which is critical for cognitive function. The research will 1)...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $742,484 to the University of Alabama at Birmingham (UAB) to characterize a genetic mouse model and delineate its function in the brain. The project aims to obtain multiome single nucleus RNA-sequencing and SNATAC-seq data, analyze and correlate these datasets, and examine chromatin state and brain morphology at key developmental time points...
This National Institute of Mental Health (NIMH) Project Grant award under the Mental Health Research Grants program (CFDA 93.242) provides $237,750 to the University of California, Merced to elucidate the neurodevelopmental functions of the SMARCC2 gene and the Brahma Associated Factor (BAF) chromatin remodeling complex. The central hypothesis is that the neuronal BAF (nBAF) complex, which includes the SMARCC2 subunit, drives RNA Polymerase 2 elongation and synapse maturation via intrinsically...
This $3,498,931 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a comprehensive study titled "Cross Scale Interrogation of NPD Genes (SING) in Mice." The primary aim is to investigate the biological pathways and neural circuit changes caused by the loss of 100 neurodevelopmental and psychiatric disorder (NPD) genes in mice. The research team at Pennsylvania State University, including the...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA on September 5, 2024. The $911,929 grant will fund a 5-year research project to combine in vivo genetic screening with spatial mapping of brain cell types to study the mechanisms by which genetic variants associated with autism spectrum disorder (ASD) and neurodevelopmental delay lead to these conditions. The project will adapt...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $682,470 to the University of California, Los Angeles (UCLA) to conduct research on the regulation of cell fate specification in the development of the human cortex. The goal is to elucidate the transcriptional mechanisms driving cortical arealization and laminar identity, which could enhance understanding of the etiology of...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $429,000.00 to the Regents of the University of Michigan to conduct research on the molecular mechanisms underlying changes in inhibitory synapses in Down syndrome. The primary goal is to discover how the overexpression of the Down Syndrome Cell Adhesion Molecule (DSCAM) gene, resulting from...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $537,754 to the Regents of the University of Michigan to conduct research on the mechanisms of neuronal temporal fate specification. The objectives are to (1) gain deeper insight into temporal fate patterning in the Drosophila brain model, and (2) explore the role of mouse...
The federal Project Grant award F31MH136735, with a total funding of $207,170.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). This grant aims to leverage large-scale genetic datasets and cutting-edge analytical methods to characterize mobile element insertions (MEIs), explore their functional implications for gene expression and splicing, and investigate their association with neurological diseases. The key...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regents of the University of Michigan. The $430,275 grant, awarded on July 1, 2024, supports research to define the mechanisms that control the competency of neural stem cells to generate intermediate progenitor cells and decommission stem cell-specific functions in these progenitors. The proposed...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research into the role of ectopic germline gene expression in neurodevelopmental disorders. The $234,000 award to the Regents of the University of Michigan will investigate whether the aberrant expression of germline-specific genes contributes to the neurological complications observed in a mouse model lacking the chromatin regulator KDM5C. The goal is to determine if this "soma-to-germline transformation" in brain cells plays a causal role in neurodevelopmental disorders like autism, schizophrenia, and intellectual disability. By examining this underexplored mechanism, the research could reveal new therapeutic targets for these conditions. The project will be conducted from July 1, 2024 to June 30, 2025 at the University of Michigan.

Generated 5/13/25, 2:32 AM