The National Institute of Mental Health (NIMH) awarded a $237,750 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Merced to elucidate the neurodevelopmental functions of the SMARCC2 gene and the broader Brahma Associated Factor (BAF) chromatin remodeling complex. The project aims to determine how the neuronal BAF (nBAF) complex, through interactions with the RNA polymerase II enzyme, regulates synapse maturation in developing neurons. This research could provide valuable insights into the epigenetic mechanisms driving normal and autism spectrum disorder-related neurodevelopment, potentially informing future treatment approaches. The award period runs from January 1, 2025 to December 31, 2026.
Generated 2/25/25, 1:47 AM