The National Institute of Mental Health (NIMH) awarded a $1,879,407 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Regents of the University of Michigan to support research on the roles of histone H3K4 methylation enzymes in neuroplasticity and synaptic scaling. The project aims to 1) map the division of labor among H3K4 methylation writer enzymes in synaptic scaling, 2) explore the mechanisms by which the KMT2A writer enzyme governs synaptic scaling induction, and 3) determine the functional interactions between H3K4 methylation writer and eraser enzymes in synaptic plasticity and behavior. Completion of this research is expected to reveal how H3K4 methylation signaling stabilizes neural networks and provide a foundation for developing evidence-based therapeutics for H3K4 methylation-related neurodevelopmental disorders.
Generated 3/4/25, 5:55 AM