Project Grant R21NS131937

Award Date 9/15/23
Completion Date 8/31/25
Dollars Obligated $421K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
The National Institute of Mental Health (NIMH) awarded Georgetown University a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to investigate how the chromatin remodeling protein CHD1 controls signaling pathways involved in synaptic homeostatic plasticity. The $1,111,187 award, effective July 15, 2024 through January 31, 2029, aims to elucidate the mechanisms by which variants in the human CHD2 gene, associated with autism spectrum disorder and other...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $270,434 to The Trustees of Princeton University to investigate the role of spatiotemporal regulation of mRNA in neuronal remodeling during morphogenesis. The research will leverage Drosophila mushroom body and dendritic arborization neurons as models to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $147,656.00 to Duke University for research investigating human-specific splicing regulation in neurogenesis and disease. The research aims to define a novel mechanism of action for human-specific non-coding genome regions in regulating post-transcriptional RNA processing...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $242,310 to Baylor College of Medicine to study the effects of the NR2E1 gene mutation on neurogenesis. The research aims to determine how the I385T mutation in the NR2E1 gene impacts its function and regulation, and how this affects cellular and behavioral outcomes in...
This Project Grant award of $481,250.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in specific neuron subtypes and contexts. The award to President and Fellows of Harvard College will enable the investigation of subcellular mechanisms controlling neural...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,847,003.00 to the Regents of the University of Michigan to develop and evaluate novel bispecific antibody-antisense oligonucleotide (BAB-ASO) conjugates that can selectively modulate gene expression in neurons. The key objectives are: 1) to test the efficacy of a...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $196,460.00 to the University of Rochester to conduct research on the role of the Integrator-Z3 module in regulating neuronal differentiation. The award, with a period of performance from December 1, 2024 to June 30, 2027, will support three primary research...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) in the amount of $164,992 will support research to elucidate the cellular and molecular mechanisms underlying autism spectrum disorder (ASD) pathology associated with CHD8 haploinsufficiency. The research will be conducted by the University of California, Davis, a leading public research institution, and will involve mapping the...
This $880,000 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will fund research at Northwestern University to investigate how the dynamic properties of mossy fiber synapses in the hippocampus contribute to an animal's ability to distinguish similar spatial representations, which is critical for episodic memory...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $419,038 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of North Dakota (UND). The funding supports the development of a miniature selective plane illumination fluorescence microscope for high-resolution volumetric imaging in freely behaving mice. This transformative machine learning-augmented microscopy platform aims to enable in...

Northwestern University received a $420,790 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) on September 15, 2023. The funding will support a research project titled "Deep Mutational Scanning of CHD2 for Variant Interpretation in Neurodevelopmental Disorders". This effort aims to develop a high-throughput assay to evaluate the functional impact of missense variants in the CHD2 gene, which is a common cause of neurodevelopmental disorders such as refractory epilepsy, intellectual disability, and autism spectrum disorders. The research approach leverages the fact that CHD2 is a chromatin remodeler to assess both downstream protein expression and DNA methylation changes as readouts of variant function. The project will also utilize prime editing technology to create a library of CHD2 variants for multiplex testing, with the goal of resolving the classification of all CHD2 variants of uncertain significance. This work has broad potential to improve genetic testing and precision medicine for patients with neurodevelopmental disorders.

Generated 7/16/24, 4:07 AM