Project Grant R01HL180319
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program for Cardiovascular Diseases Research (CFDA 93.837), provides $123,104 to Emory University to conduct research on factors contributing to cardiovascular disease (CVD) comorbidities in persons living with HIV (PWH). The key objectives are to: 1) assess relationships between the metabolome, lipidome, HIV reservoir, and subclinical CVD, analyzing differences by sex; and 2) determine...
- This federal Project Grant award of $198,549.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research to determine the contribution of HIV and menopausal phase to cardiovascular disease (CVD) risk parameters and subclinical atherosclerosis in women with HIV. The study aims to (1) assess the association of HIV and menopausal phase with CVD risk factors, (2) evaluate the relationship between HIV, menopausal phase, immune...
- The National Heart Lung and Blood Institute (NHLBI) awarded a $3,264,423 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) to study the mechanisms underlying the increased risk of sudden cardiac death in people with HIV. The research aims to characterize the myocardial tissue effects of treated HIV, including immune activation, cardiac ion channel dysregulation, and region-specific arrhythmic...
- This $525,095 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify novel cellular determinants of human cytomegalovirus (HCMV) infection. The University of Rochester, the primary awardee, aims to: Elucidate the mechanisms through which the cellular factor JUNB can restrict HCMV infection. JUNB is a stress-induced transcription factor that regulates...
- This $798,698 project grant, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to comprehensively characterize cardiac and physical function in youth with perinatally-acquired HIV (YPNHIV) compared to HIV-unexposed (HU) and HIV-exposed uninfected (PHEU) individuals. The research will utilize cardiac imaging, physical function assessment, autonomic dysfunction analysis, and molecular profiling to elucidate determinants of...
- This Project Grant award of $426,939 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, supports research to investigate how the cytomegalovirus (CMV) "temperance factor" RL13 modulates viral replication. The research aims to understand how and why RL13 represses CMV replication, with the overarching hypothesis that RL13 is regulated to modulate CMV replication in different settings. The project...
- This federal Project Grant award of $115,125.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the interaction between obstructive sleep apnea (OSA) and HIV infection on ventricular repolarization abnormalities. The research will be conducted by the University of Miami from February 1, 2025 to January 31, 2027. The goal is to delineate the independent and interactive effects of OSA and HIV on QT variability...
- This $252,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support a study to examine the relationship between menopausal hormone therapy, the gut microbiome, and estrogen-related outcomes in women with HIV. The study, to be conducted by the Albert Einstein College of Medicine, will perform shotgun metagenomic sequencing of gut microbiome samples collected before and after a 12-week randomized, double-blinded,...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $682,879 to The Medical College of Wisconsin, Inc. to conduct research on the impacts of human cytomegalovirus (HCMV) infection on human neural tissue development. The project aims to (1) define the transcriptional and cellular disruptions to developing human neural cells caused by HCMV infection, (2) determine...
- This federal Project Grant award for $711,993.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to examine the effects of Mycobacterium tuberculosis (MTB) disease on HIV-1 pathogenesis in people living with HIV (PWH). The research aims to assess how MTB disease influences the development of broadly neutralizing HIV-1 antibodies, the emergence of NAb-resistant viral...
This federal Project Grant award of $2,981,544.00, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund a study to assess the impact of asymptomatic cytomegalovirus (CMV) infection on cardiovascular event risk in people with treated HIV infection. The study will leverage data from a prior clinical trial of the CMV-specific antiviral drug letermovir and a case-cohort study of over 1,900 ART-suppressed people with HIV to perform a large-scale Mendelian randomization analysis. This will examine whether CMV-associated plasma proteomic signatures and CMV-specific neutralizing antibody titers are causally linked to cardiovascular and venous thromboembolism risks, particularly in women with HIV. The project aims to identify potential therapeutic targets to reduce inflammation-associated vascular disease in this population. The award period runs from Aug 15, 2025 to Jul 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 9/19/25 | ||
| Not listed | ($768k) | 9/17/25 | ||
| Not listed | $768.0k | 8/13/25 |