Project Grant R01HL178399
- The National Heart Lung and Blood Institute (NHLBI), under CFDA Program 93.837 Cardiovascular Diseases Research, awarded a $3,519,835 Project Grant to the Scripps Research Institute in La Jolla, CA on September 5, 2025. The grant, titled "PLANB2CUREHIV (THE 'PLANB' CONSORTIUM) - PROJECT SUMMARY", aims to accelerate the preclinical development of safe and effective genome-edited B cell-based therapies that could provide long-lasting, broadly neutralizing antibody titers capable of...
- This $798,698 project grant, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to comprehensively characterize cardiac and physical function in youth with perinatally-acquired HIV (YPNHIV) compared to HIV-unexposed (HU) and HIV-exposed uninfected (PHEU) individuals. The research will utilize cardiac imaging, physical function assessment, autonomic dysfunction analysis, and molecular profiling to elucidate determinants of...
- This federal Project Grant award of $115,125.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the interaction between obstructive sleep apnea (OSA) and HIV infection on ventricular repolarization abnormalities. The research will be conducted by the University of Miami from February 1, 2025 to January 31, 2027. The goal is to delineate the independent and interactive effects of OSA and HIV on QT variability...
- This federal Project Grant award of $2,981,544.00, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund a study to assess the impact of asymptomatic cytomegalovirus (CMV) infection on cardiovascular event risk in people with treated HIV infection. The study will leverage data from a prior clinical trial of the CMV-specific antiviral drug letermovir and a case-cohort study of over 1,900 ART-suppressed people with HIV to...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program for Cardiovascular Diseases Research (CFDA 93.837), provides $123,104 to Emory University to conduct research on factors contributing to cardiovascular disease (CVD) comorbidities in persons living with HIV (PWH). The key objectives are to: 1) assess relationships between the metabolome, lipidome, HIV reservoir, and subclinical CVD, analyzing differences by sex; and 2) determine...
- This federal Project Grant award of $198,549.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research to determine the contribution of HIV and menopausal phase to cardiovascular disease (CVD) risk parameters and subclinical atherosclerosis in women with HIV. The study aims to (1) assess the association of HIV and menopausal phase with CVD risk factors, (2) evaluate the relationship between HIV, menopausal phase, immune...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $540,856 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) on Dec 15, 2024. The goal of this 4-year project is to identify transcriptional regulators that control endocardial-specific gene expression and valve development, as well as understand the regulation and function of the SLC16A2 gene during heart injury and regeneration. The...
- This Project Grant award of $1,289,113 was provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to the Oregon Health & Science University. The funding supports the IPRISM (Imaging-Enhanced Prediction of Risk for Sudden Cardiac Death in HCM) research project, which aims to improve the ability to predict sudden cardiac death risk in children and adolescents with hypertrophic cardiomyopathy. Key activities...
- This $556,295 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance scientific understanding of cardiac pacemaking and sinus node dysfunction (SND) through research on "conditional pacemaker cells" within distinct specialized pacemaker cell subpopulations. The project will leverage advanced optical mapping technology to directly visualize pacemaking activities within these specialized cell...
- The University of California, San Francisco (UCSF) was awarded a $897,989 Project Grant by the National Institute on Minority Health and Health Disparities (CFDA 93.307 - Minority Health and Health Disparities Research) on September 13, 2025. The grant funds a study to understand the hypertension (HTN) care cascade and cardiovascular disease risk among people with HIV who receive care at a safety net clinic, with a focus on the unique HTN care needs of those with severe financial challenges. The...
The National Heart Lung and Blood Institute (NHLBI) awarded a $3,264,423 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) to study the mechanisms underlying the increased risk of sudden cardiac death in people with HIV. The research aims to characterize the myocardial tissue effects of treated HIV, including immune activation, cardiac ion channel dysregulation, and region-specific arrhythmic substrate. The project will leverage UCSF's Postmortem Systematic Investigation of Sudden Cardiac Death study, a unique resource for studying the direct myocardial tissue impacts of HIV in victims of sudden cardiac death, the majority of whom were receiving antiretroviral therapy. The grant award period runs from September 1, 2025 through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.3m | 9/19/25 | ||
| Not listed | ($820k) | 9/17/25 | ||
| Not listed | $819.7k | 8/19/25 |