This $123,104 five-year Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research on the relationships between the HIV reservoir, metabolome, lipidome, and subclinical cardiovascular disease (CVD) in persons with HIV, with a focus on sex differences. The principal investigator, an associate professor at Emory University, will leverage an established cohort with over 50% women to assess how the metabolome, lipidome, and HIV reservoir size relate to subclinical CVD. The research aims to uncover sex-specific multi-omic signatures associated with increased CVD risk among those with larger HIV reservoirs. The grant will also support the PI's efforts to enhance their mentoring program and develop new skills in lipidomics, high-resolution metabolomics, and multi-omic data integration to advance this line of patient-oriented research. The award commenced on January 1, 2025 and is set to conclude on December 31, 2029.
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