Project Grant R03HL182350
- This federal Project Grant award of $198,549.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research to determine the contribution of HIV and menopausal phase to cardiovascular disease (CVD) risk parameters and subclinical atherosclerosis in women with HIV. The study aims to (1) assess the association of HIV and menopausal phase with CVD risk factors, (2) evaluate the relationship between HIV, menopausal phase, immune...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $2,461,651.00 to the University of Texas Health Science Center at Houston to investigate the impact of estrogen on IgG glycosylation and its effects on immune function and inflammation in people with HIV. The research aims to determine if estrogen can reverse the HIV-associated loss of IgG galactose, which has been linked to reduced antiviral...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program for Cardiovascular Diseases Research (CFDA 93.837), provides $123,104 to Emory University to conduct research on factors contributing to cardiovascular disease (CVD) comorbidities in persons living with HIV (PWH). The key objectives are to: 1) assess relationships between the metabolome, lipidome, HIV reservoir, and subclinical CVD, analyzing differences by sex; and 2) determine...
- This federal Project Grant award of $2,981,544.00, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund a study to assess the impact of asymptomatic cytomegalovirus (CMV) infection on cardiovascular event risk in people with treated HIV infection. The study will leverage data from a prior clinical trial of the CMV-specific antiviral drug letermovir and a case-cohort study of over 1,900 ART-suppressed people with HIV to...
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $720,399 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Colorado-Denver. The 5-year project, running from Sep 1, 2025 to May 31, 2030, will investigate the associations between maternal microbiomes, metabolomes, and cardiovascular health outcomes in a racially and ethnically diverse pregnancy cohort. Key objectives are to characterize...
- This Project Grant award from the Department of Health and Human Services' National Institutes of Health (CFDA 93.310 - Trans-NIH Research Support) provides $703,644 to the Icahn School of Medicine at Mount Sinai to investigate the drivers of accelerated aging in people living with HIV (PWH). The research aims to study the effects of HIV and antiretroviral therapy on epigenetic aging and clonal hematopoiesis, as well as examine the role of socio-behavioral factors and genetic predisposition in...
- This federal Project Grant award of $433,125.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the role of sex hormones in influencing host-microbiome interactions in the human oral mucosa. The award will fund a 5-year project from August 1, 2025 to April 30, 2030, conducted by the University of Massachusetts Lowell. The research aims to develop a mechanistic...
- This $421,250 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to elucidate how lifestyle factors such as diet, exercise, and social interactions shape the gut microbiome's contributions to human metabolic health. Over the 5-year grant period from September 2025 to June 2030, the research will be conducted by the President and Fellows of Harvard College. The...
- This Project Grant award of $429,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Colorado-Denver aims to investigate the relationship between gut microbiota dynamics, exercise, and physical function among older adults with HIV. The research project will examine how exercise-induced changes in the gut microbiome may contribute to improvements in physical function for this population, which has been observed to experience impairments in physical...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $249,000.00 in funding to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System) to develop methodologies for revealing the role of the blood microbiome in the gut-lung axis for asthma pathogenesis. The key products and services to be delivered include: A strain-resolved computational pipeline for reduced metagenomic sequencing to...
This $252,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support a study to examine the relationship between menopausal hormone therapy, the gut microbiome, and estrogen-related outcomes in women with HIV. The study, to be conducted by the Albert Einstein College of Medicine, will perform shotgun metagenomic sequencing of gut microbiome samples collected before and after a 12-week randomized, double-blinded, placebo-controlled trial of estradiol in 105 women with HIV aged 40-60 years. The specific aims are to: 1) determine the effect of menopausal hormone therapy on the gut microbiome, and 2) examine whether the gut microbiome can enhance the efficacy of estrogen-based menopausal hormone therapy for improving menopausal symptoms and cardiovascular health in this population. The award period runs from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $252.0k | 8/28/25 |