The National Heart, Lung, and Blood Institute (NHLBI) awarded a $115,125 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Miami to investigate the interaction between obstructive sleep apnea (OSA) and HIV on ventricular repolarization abnormalities. The project aims to delineate the independent and interactive effects of OSA and HIV on QT variability index (QTVI), a predictor of ventricular arrhythmias and sudden cardiac death, in a cohort of 851 men living...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,454,724 to the University of Pittsburgh to understand the mechanisms of HIV-1 latency in the central nervous system (CNS). The research aims to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cells, which serve as viral reservoirs in...
This federal Project Grant award, totaling $131,922, was provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The award, with a start date of August 15, 2024 and an end date of May 31, 2029, is aimed at tracking myeloid cell heterogeneity in mouse models and cerebrospinal fluid of HIV-suppressed individuals to classify neuroinflammation and identify molecular markers associated with cognitive impairment. The...
The federal Project Grant award R01HL176991 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The $594,547 grant supports research to characterize a gut-to-brain signaling pathway that uses information about ingested nutrients to control arousal from sleep and sleep quality, without affecting sleep duration. The research team at Harvard Medical School aims to elucidate how dietary proteins are sensed in the gut...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $421,800.00 to Midwestern University to explore the effects of chronic intermittent hypoxia on cholinergic modulation at hypoglossal motoneurons. The project will use immunofluorescence and electrophysiology techniques to evaluate neuroanatomical and functional changes in cholinergic signaling at hypoglossal motoneurons in mice...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $880,000 to Old Dominion University (ODU) and its research foundation (Odurf) to investigate the therapeutic effects of microglia depletion and repopulation (MGDR) on mitigating hand and neuropsychiatric symptoms in individuals with chronic HIV infection. The research aims to determine if MGDR can restore brain function and address the pathology associated with HIV-related neurological deficits....
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), aims to determine nasal mucosal immune and microbiome alterations and their clinical implications among people living with HIV (PLWH) compared to seronegative individuals. The total award amount is $1,297,878 with a performance period from August 15, 2024 to June 30, 2029. The research will characterize the nasal immune...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $498,000.00 to the University of Florida to investigate the role of microglia activation and neuroinflammation in the pathophysiology of pulmonary hypertension (PH). The key objectives are to: 1) Evaluate microglia-dependent mechanisms contributing to increased preautonomic neuron activity in the paraventricular nucleus; 2) Determine how TREM2 expression...
This Project Grant award, totaling $771,902, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award will fund research at Brigham & Women's Hospital to investigate how extracellular vesicles containing the HIV-associated protein Nef (Nef EVs) modulate macrophage heterogeneity and impair efferocytosis, potentially contributing to accelerated atherosclerosis in people living with HIV. The...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $641,960 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the Augusta University Research Institute, Inc. (dba Georgia Health Sciences) to study the mechanisms of HIV-associated hypertension. The 4-year project (9/1/2024 - 8/31/2028) will investigate how HIV-derived proteins, particularly the Tat protein, induce hypertension through inflammation, oxidative stress, and endothelial dysfunction. The research aims to...