This Project Grant award of $1,917,649, provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to characterize nasal mucosal immune and microbiome alterations and their clinical implications among people living with HIV (PLWH) compared to seronegative individuals. The primary awardee, the University of North Carolina at Chapel Hill, will conduct this research through three key aims: 1) characterizing the nasal immune environment, 2) profiling the nasal microbiome, and 3) defining nasal mucosal endotypes associated with pulmonary consequences in PLWH. The research includes longitudinal assessments to understand variability in these measures. A sub-award to the University of Pittsburgh will contribute to participant recruitment, sample collection, and data reporting for the study. Successful completion of this project is expected to provide valuable insights to guide therapeutic strategies and interventions for modifying nasal mucosal inflammation and microbiome in this vulnerable population.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $619.8k | 6/27/25 | ||
| Not listed | $0 | 2/14/25 | ||
| Not listed | $0 | 2/14/25 | ||
| Not listed | $648.9k | 8/9/24 | ||
| Not listed | $648.9k | 8/9/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
5133198S | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Project Grant R01HL176283 | $106.0k | 1/21/25 |