This $818,886 Project Grant awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) will fund a research project at the University of California, San Diego (UCSD) to characterize the epigenetic regulation of the HIV provirus in brain myeloid cells from people with HIV (PWH). The key objectives are to: 1) use single-cell sequencing to analyze epigenetic regulators of the HIV provirus in brain myeloid cells from 15 PWH;...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,454,724 to the University of Pittsburgh to understand the mechanisms of HIV-1 latency in the central nervous system (CNS). The research aims to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cells, which serve as viral reservoirs in...
The U.S. National Institute on Aging (NIA) awarded a $383,750 Project Grant under the Aging Research program (CFDA 93.866) to the University of Nebraska Medical Center (UNMC) to explore the molecular, neuro-immune, and behavioral changes that occur during HIV-associated progressive aging using a long-term humanized mouse model. The project aims to decipher how antiretroviral therapy (ART)-mediated viral suppression affects aging and brain immune homeostasis in people living with HIV,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $880,000 to Old Dominion University (ODU) and its research foundation (Odurf) to investigate the therapeutic effects of microglia depletion and repopulation (MGDR) on mitigating hand and neuropsychiatric symptoms in individuals with chronic HIV infection. The research aims to determine if MGDR can restore brain function and address the pathology associated with HIV-related neurological deficits....
The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants is focused on investigating the role of the PERK kinase in HIV-induced neuroinflammation and neurocognitive impairment. The $745,822 award will fund a 5-year research project led by The Trustees of the University of Pennsylvania. Key objectives include assessing the cell-specific mechanisms by which PERK contributes to neuronal, astrocytic, and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $794,341 will support research to investigate the mechanistic roles of cellular senescence and blood-brain barrier dysfunction in mediating pathogen-induced progression of Alzheimer's disease. The research will leverage experimental mouse models, molecular characterization of endogenous retrovirus RNA sensing, and human induced pluripotent stem cell (iPSC) models. Key objectives...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the host-pathogen dynamics between the pathogen Cryptococcus neoformans (CN) and HIV in microglia cells. The $232,073 award, active from November 2024 to October 2026, aims to explore the impact of CN replicative aging on its survival and growth in the central nervous system of AIDS patients....
The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), has awarded a $534,644.00 Project Grant to Temple University - Of The Commonwealth System Of Higher Education. The grant aims to characterize how the HIV-1 virus decreases neuronal clearance, leading to the progression of HIV-associated neurocognitive disorders like motor dysfunction. Key research activities include determining the post-translational regulation of the SNAPIN protein and its impact on...
This $498,444 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) supports research to investigate the effects of HIV-associated extracellular vesicles on mitochondrial dysfunction and blood-brain barrier disruption in brain microvessels. The research, conducted by Tulane University, aims to understand the mechanisms underlying HIV-associated neurocognitive disorders (HAND) and explore the...