Project Grant R01HL179883

Award Date 5/15/25
Completion Date 3/31/30
Dollars Obligated $715K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Texas, USA
Similar Awards
This $169,560 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of PERK/ATF4 endoplasmic reticulum (ER) stress response and MLL1-mediated CHOP expression in vascular smooth muscle cell (VSMC) dysfunction and apoptosis during the development of abdominal aortic aneurysms (AAAs). The research aims to elucidate the...
This R01 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $786,060 to Vanderbilt University Medical Center to investigate how hypertension-induced trained immunity in myeloid cells contributes to atherosclerosis and chronic inflammation. The key objectives are to: Determine how hypertension rewires the epigenome and cell state of mature monocytes to promote pro-atherogenic and pro-inflammatory...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, provides $114,938 to Brigham & Women's Hospital Inc. to conduct research on identifying novel epigenetic mechanisms underlying calcific aortic valve disease. The key objectives of this 2-year project are to: 1) define the histone code of calcific aortic valve disease and corresponding transcriptional regulation; 2) determine...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Program (CFDA 93.837) provides $705,944 to Yale University to conduct research on understanding the mechanisms underlying thoracic aortopathy, including aneurysm, dissection, and rupture. The project aims to quantify the transcriptional profile and biomechanical phenotype of the aorta in three mouse models of Marfan syndrome, using consistent methods to determine...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, supports research on CAMK4 as a regulator of inflammation resolution and trained immunity in atherosclerosis. The primary aims are to explore how trained immunity impairs efferocytosis, a key process in resolving inflammation, and to investigate the role of CAMK4 in trained immunity development. The total award amount is $100,325, provided...
This federal Project Grant award of $840,873 from the National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), supports research under the Cardiovascular Diseases Research program (CFDA 93.837). The primary objective is to elucidate the role of epitranscriptional regulation, specifically the N6-methyladenosine (m6A) modification, in endothelial cell function and atherosclerosis development under different blood flow patterns. Key research...
This Project Grant award, valued at $1,419,308 and spanning from September 2024 to August 2025, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The award supports research to investigate the mechanisms linking persistent DNA damage to the upregulation of the NLRP12 gene, and the functional implications of this link in aging hematopoiesis. The research aims to establish a novel interplay between persistent DNA...
This federal Project Grant award for $2,508,095.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research to elucidate the role of aberrant cell-extracellular matrix interactions in the progression of thoracic aortic disease. The 5-year project, awarded to Yale University, will test the hypothesis that dysfunctional mechano-sensing and mechano-regulation of the aortic extracellular matrix by smooth...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of the bromodomain protein BRD4 and its downstream target CEBPD in the progression of abdominal aortic aneurysm (AAA). The $2,813,428 award to the University of Virginia aims to advance the understanding of the molecular mechanisms underlying AAA development, with the goal of identifying novel...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $686,640 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division. The grant, titled "Finding and Pushing the Limits of Macrophage Efferocytosis in Atherosclerosis," aims to uncover new insights into therapeutic opportunities targeting macrophage efferocytosis (the clearance of dead cells) to mitigate the...

This $715,180 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to understand the epigenetic regulation of trained immunity in thoracic aortic aneurysms and dissections (ATAAD). The project aims to determine the sites and mechanisms of immunity training in monocytes/macrophages, and the role of the STING-IRF3/IRF4 pathway in driving pro-inflammatory macrophage phenotypes during ATAAD development. The research will integrate single-cell sequencing analyses of bone marrow and aortic tissue samples from mice and ATAAD patients to characterize the epigenetic signatures and functional states of trained macrophages. This work is expected to provide new insights into the molecular mechanisms driving persistent aortic inflammation and degeneration, potentially leading to new treatment strategies for preventing ATAAD and related cardiovascular diseases.

Generated 5/13/25, 4:21 AM