This $169,560 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by the Regents of the University of Michigan to study the role of the PERK/EIF2A/ATF4 endoplasmic reticulum (ER) stress response and MLL1-mediated regulation of the CHOP gene in the development of abdominal aortic aneurysms (AAAs).
The research aims to elucidate the impact of ER stress signaling on vascular smooth muscle cell (VSMC) apoptosis in AAAs, determine MLL1's regulation of CHOP expression in AAA VSMCs, and examine the therapeutic potential of inhibiting the ATF4-MLL1-CHOP pathway to prevent AAA expansion. This translational research is expected to advance understanding of ER stress in AAA pathogenesis and support the development of preventive therapeutic agents targeting VSMC dysfunction to limit AAA progression.
Generated 3/18/25, 4:11 AM