Project Grant R35HL177389

Award Date 5/1/25
Completion Date 4/30/32
Dollars Obligated $687K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,070,048 to The Trustees of Columbia University in the City of New York to investigate cellular and molecular mechanisms underlying plaque stability and destabilization in atherosclerosis. The overarching goal is to understand how macrophage inflammation and efferocytosis (clearance of dead cells) regulate plaque stability...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,127,798 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for the period of February 1, 2025 to January 31, 2032. The grant supports a comprehensive research program to understand the role of macrophages in preserving cardiovascular health, illuminate their contributions to cardiovascular disease (CVD), and...
The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $666,072 project grant under the Cardiovascular Diseases Research (CFDA 93.837) program to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated. The grant, titled "LNCRNA MERRICAL, MACROPHAGE CHEMOTAXIS, AND DIABETES-ASSOCIATED ATHEROSCLEROSIS," aims to investigate the role of the long non-coding RNA (lncRNA) MERRICAL in regulating macrophage chemotaxis and inflammation, with the...
This $784,206 federal Project Grant award issued by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research on the role of the CSF-1/CSF-1R axis in myocardial infarction (MI) repair and remodeling. The research aims to examine the in vivo effects of macrophage-specific CSF-1R activation, investigate the role of fibroblast-derived CSF-1, evaluate the therapeutic potential of early CSF-1/CSF-1R axis activation, and...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), will provide $381,250 to Clemson University to conduct research on identifying novel atheroprotective mechanisms related to vascular smooth muscle cell cholesterol efflux. The research aims to rigorously analyze the potential atheroprotective impacts of increased expression of the ABC transporters ABCA1 and ABCG1 in...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $787,267 to Yale University to conduct research on the role of cholesterol biosynthetic intermediates and derivatives in modulating the immune response of macrophages in atherosclerosis. The award aims to determine whether genetic deletion of the DHCR24 enzyme in macrophages can attenuate atherosclerosis progression, and whether...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $2,229,404 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Yale University to investigate the role of novel lysoplasmalogenase enzymes in regulating macrophage immunometabolic responses in cardiovascular disease. The project aims to elucidate how the LXR/miR-33/TMEM86A signaling pathway contributes to chronic vascular inflammation in atherosclerotic lesions. Yale will utilize cutting-edge genomic and metabolomic...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $771,750 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of California, Los Angeles (UCLA) to investigate the role of macrophages in regulating cardiac muscle metabolism following a myocardial infarction. The 4-year research project aims to shed novel insight into how bone marrow macrophages that infiltrate the infarcted heart disrupt cardiac muscle energetics and function, and...
This $1,875,540 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), aims to investigate the role of perivascular macrophages in promoting endothelial cell regeneration and vascular repair following acute lung injury or acute respiratory distress syndrome (ARDS). The key objectives are to (1) determine how perivascular macrophages regulate endothelial cell regeneration and vascular repair...
The National Institutes of Health National Heart Lung and Blood Institute awarded a $511,680 Project Grant to the University of Illinois under the Cardiovascular Diseases Research program (CFDA 93.837). The grant will fund research from February 2021 through August 2021 to investigate mechanisms by which vascular endothelial cells instruct macrophage fate in inflammatory injury. Specifically, the research will examine how endothelial cell Wnt signaling licenses the differentiation of monocytes...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $686,640 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division. The grant, titled "Finding and Pushing the Limits of Macrophage Efferocytosis in Atherosclerosis," aims to uncover new insights into therapeutic opportunities targeting macrophage efferocytosis (the clearance of dead cells) to mitigate the residual risks associated with atherosclerotic cardiovascular disease (ACVD). The 7-year project, commencing on May 1, 2025, leverages integrative genomic, functional genomic, and imaging-based screening to identify and validate regulators of macrophage efferocytosis that could serve as novel therapeutic targets for ACVD and other diseases with defective efferocytosis.

Generated 5/13/25, 5:09 AM