Project Grant R01HL170107

Award Date 7/1/24
Completion Date 6/30/28
Dollars Obligated $841K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
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This federal Project Grant award under CFDA 93.837 "Cardiovascular Diseases Research" was provided by the National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), to the University of California, San Diego. The total award amount is $840,873.00 with a period of performance from July 1, 2024 to June 30, 2028.

The purpose of this grant is to elucidate the role of RNA epitranscriptional regulation, specifically the N6-methyladenosine (m6A) modification, in endothelial cell function and atherosclerosis development. The research aims to delineate the dynamics of METTL3-regulated m6A epitranscriptomes in endothelial cells under different blood flow patterns, identify the METTL3-modulated m6A RNA targets that drive atheroprone flow-enhanced glycolysis and pentose phosphate pathway, and validate the flow regulation of METTL3 and m6A epitranscriptomes in mouse atherosclerosis models. A $167,708.00 sub-award was made to the Beckman Research Institute of the City of Hope to leverage their expertise in multi-omics sequencing and spatial transcriptome mapping for portions of the research.

This interdisciplinary project seeks to unveil novel epitranscriptional mechanisms underlying endothelial cell mechanobiology and atherosclerotic disease progression, with the ultimate goal of advancing scientific understanding and identifying potential therapeutic targets.

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