The National Heart, Lung, and Blood Institute (NHLBI) awarded a $543,268 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the Beckman Research Institute of the City of Hope to conduct research on "RNA-Mediated Endotheliopathy in Diabetic Vasculopathy." The project aims to elucidate the epigenetic and epitranscriptional mechanisms underlying diabetes-associated endothelial dysfunction and develop novel nanotherapeutics to ameliorate diabetic vascular disease, with a...
This $717,415 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the critical roles of RNA 5-methylcytosine (m5C) and its regulatory axis in hematopoietic stem/progenitor cell (HSPC) function. The award recipient, the University of Texas Health Science Center at San Antonio, will study how the TET2 enzyme's oxidation of m5C on chromatin-associated RNAs (CARNAs)...
This federal Project Grant award, valued at $2,466,322.00 and provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into the mechanisms by which the histone methyltransferase MLL1 regulates gene expression related to endothelial inflammation and thrombosis in severe SARS-CoV-2 infection. The key objectives are to: 1) determine how MLL1 targets promotor regions of genes involved in endothelial cell...
This federal Project Grant award of $213,284 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research to investigate the regulation of endothelial hemoglobin alpha (HBA) by iron homeostasis. The central hypothesis is that the regulation of endothelial function by systemic iron levels depends on intracellular iron and heme availability, which work together to control HBA expression. The research will use...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Program (CFDA 93.837), is funding research to investigate the critical role of fluid shear stress from blood flow on the vascular endothelium and its impact on atherosclerosis. The $2,395,029 grant will support a comprehensive analysis of the effects of laminar vs. disturbed shear stress on endothelial cell metabolism, the role of the mechanosensitive channel Piezo1,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) will provide $706,220 to the University of Illinois to conduct research on the role of nuclear pore components in vascular function and atherosclerosis. The research aims to elucidate how phosphorylation of the nucleoporin NUP93 affects nuclear localization of the transcriptional co-factor YAP, and how this impacts endothelial cell...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $705,405.00 to The Leland Stanford Junior University to conduct research on the role of adventitial fibroblasts in atherosclerosis. The key objectives are to determine the mechanism by which targeted genetic ablation of adventitial fibroblasts decreases plaque formation, understand how conditional deletion of the TCF21 gene...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $684,794 to the University of California, Merced to conduct research on the role of the blood vascular system and endothelial cells in the regeneration of the thymus after cytotoxic treatments. The research aims to utilize novel intravital imaging techniques to directly characterize the thymic vascular physiology, define...
The University of Arizona was awarded a $625,316 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the role of RNA methylation and translational regulation in the oxidative stress response of heart failure. The research aims to elucidate how the YTHDF2 protein binds to methylated NRF2 mRNA to selectively induce its translation under oxidative stress, a process that may be impaired in end-stage heart failure. The...
This Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to understand the role of the emerin (EMD) gene and its regulation by secretory trafficking in human atrial cardiomyocytes. The $205,469 award, with a period of performance from September 30, 2024 to April 30, 2026, will support research at the University of California, San Francisco (UCSF) to manipulate emerin localization in human...