This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research to elucidate mechanisms underlying thoracic aortopathy, a significant cause of morbidity and mortality. The $705,944 award to Yale University, with a period of performance from July 2024 to June 2028, will fund the use of consistent methods to quantify the transcriptional profile and biomechanical phenotype of the...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $798,343 to Yale University to conduct research on the role of endothelial cell metabolism and cell cycle regulation in mediating the effects of fluid shear stress on the vascular endothelium in health and disease. The award period runs from August 13, 2024 to May 31, 2028. The research aims to gain a thorough, unbiased...
This $169,560 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to elucidate the role of the PERK/EIF2A/ATF4 endoplasmic reticulum (ER) stress response and MLL1-mediated CHOP expression in vascular smooth muscle cell (VSMC) apoptosis and abdominal aortic aneurysm (AAA) development. The project will investigate these mechanisms in human and murine AAA models with the aim of...
This Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will support a quantitative, predictive model of vascular remodeling in health and disease. The $686,458 award, provided from July 2024 through May 2028, will enable the research team from Yale University to acquire quantitative data on interactions within vascular remodeling regulatory networks and develop a computational model to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $462,133 to Yale University from September 1, 2024 to June 30, 2028 to construct a molecular atlas of mitral valve disease using single-cell and spatial multi-omics analysis. The research aims to accurately identify cell subpopulations and molecular states in mitral valve prolapse (MVP), characterize the tissue microenvironment...
This $2,813,428 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to better understand and mitigate abdominal aortic aneurysm (AAA). The award recipient, the University of Virginia, will investigate the role of the protein BRD4 and associated transcription factor CEBPD in regulating smooth muscle cell inflammation and degeneration that drives AAA progression. Leveraging genome-wide...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $787,267 to Yale University to conduct research related to the regulation of cholesterol and immune responses in cardiometabolic diseases, including atherosclerosis. The funded project aims to determine whether genetic deletion of the DHCR24 enzyme in macrophages and hepatocytes can attenuate the progression of atherosclerosis by...
This $1,927,989 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to understand the mechanisms and develop therapies for congenital aortic valve disease. The awardee, the Research Institute at Nationwide Children's Hospital, will utilize a new mouse model of congenital aortic valve stenosis to define the underlying molecular pathways, examine disease progression, and test potential...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $569,891.83 to Yale University from July 1, 2024 to June 30, 2027. The goal is to develop a computational model that can predict the propensity for heart failure after myocardial infarction. This will involve refining and validating a multiscale model that combines cell-scale cardiac growth and remodeling with organ-scale cardiac...
This $226,784 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research on the role of the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO) in the initiation and progression of abdominal aortic aneurysm (AAA). The study aims to determine how TMAO-mediated activation of the protein kinase PERK in vascular smooth muscle cells (VSMCs) contributes to AAA development. The research...