This Project Grant award from the National Institute on Aging provides $2,797,356 to the University of Pittsburgh to support research into DNA damage-induced inflammation and its brain-specific consequences from April 15, 2022 through March 31, 2025. The award is being made under the Aging Research program (CFDA 93.866), which aims to further the understanding of aging and age-related diseases. Specifically, the University of Pittsburgh will conduct research exploring cytoplasmic DNA (cytDNA) as...
The federal Project Grant award of $146,922 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the mechanisms underlying hematopoietic stem and progenitor cell (HSPC) dysfunction in myelodysplastic syndromes (MDS). The research focuses on understanding how environmental factors and age-related inflammation, mediated by the cGAS-STING pathway and neutrophil dysfunction, interact with the...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $465,000.00 to Bloodworks (formerly Puget Sound Blood Center and Program) to investigate the mechanisms by which chronic inflammation disrupts autophagy and mitophagy in platelets and red blood cells in sickle cell disease. The research aims to elucidate how inflammation-driven dysfunction of these critical cellular processes...
This $653,854 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The purpose of the grant is to study the impact of cardiomyocyte-selective modulation of natriuretic peptide signaling pathways on cardiomyopathy progression and ventricular arrhythmia susceptibility in preclinical models. The specific aims are to: 1) Define how cardiomyocyte-specific modulation of PKG1 activity modifies cardiomyopathy...
This federal Project Grant award for $373,500.00, funded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will support a secondary analysis of existing datasets to define the neutrophil transcriptomic response to parenchymal damage. The research aims to identify and validate a targeted neutrophil gene expression program specific to parenchymal damage, define the dynamic expression of this program in the development of...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $802,301 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Weill Medical College of Cornell University. The grant aims to identify the mechanisms that control the "stem cell niche" - the microenvironment that regulates blood stem cells - in the context of clonal hematopoiesis, a condition where mutated blood stem cells expand and increase the risk of life-threatening diseases. The research...
This federal Project Grant award of $395,314 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to define the innate immune cell profile and cytokine microenvironment that mediate the development of inhibitory antibodies against factor VIII in individuals with hemophilia A. The research aims to 1) examine the cytokine profile and activation of conventional dendritic cells (CDC2) that drive CD4+ T cell...
This $607,952 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pittsburgh to investigate indole metabolites as novel danger signals that activate regulated cell death pathways in lung epithelial cells, which may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The key research objectives include...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $445,000.00 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the role of neutrophil extracellular traps (NETs) in thromboinflammatory diseases. The research aims to characterize the role of NETs in immune homeostasis, define the mechanisms by which platelet factor 4 (PF4) and an Fc-modified anti-PF4...
This federal Project Grant award, valued at $2,241,717.00 and provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research aimed at defining the spatiotemporal profile and cellular heterogeneity of marginal zone B and B1 cell-specific protein (MZB1)+ B and plasma cell populations in the development of chronic rejection after lung transplantation. The overarching goal is to interrogate the mechanistic...