Project Grant R01HL179286
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $718,824 in project grant funding (R01HL188006) on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research into the mechanisms by which electronic cigarette exposure drives vascular injury and atherosclerosis progression through the glutamate N-methyl-D-aspartate receptor (NMDAR) pathway in vascular smooth muscle cells. The research comprises three...
- The National Heart, Lung, and Blood Institute awarded The Regents of the University of California, San Francisco $127,168 on April 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to model the effect of apolipoprotein L1 risk variants on cardiovascular disease risk in African American e-cigarette users. The research employs human induced pluripotent stem-cell-derived endothelial cells to investigate how e-cigarettes, with and without menthol, affect endothelial health in...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $821,294 to The Trustees of Columbia University in the City of New York on September 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Project Grant R01HL179303). The award funds the VAPESCAN study, a longitudinal investigation examining early lung toxicity associated with e-cigarette versus cigarette use in young adults aged 18–50....
- The National Heart Lung and Blood Institute awarded $827,439 to Lundquist Institute For Biomedical Innovation At Harbor-UCLA Medical Center on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate mechanisms by which perinatal nicotine vaping exposure dysregulates pulmonary group 2 innate lymphoid cells (ILC2s) and promotes allergic asthma development in offspring. The research employs electronic nicotine delivery system (ENDS) exposure models and...
- The National Institute of Environmental Health Sciences awarded Wayne State University $473,313 on September 3, 2026, under the Environmental Health program (CFDA 93.113) to investigate how acid, base, and salt components of electronic cigarettes affect fetal lung development and immune function during pregnancy. The project examines sex-specific impacts of e-cigarette aerosols on neonatal respiratory health using a preclinical pregnant rat model with a state-of-the-art vaping system that...
- The National Institutes of Health awarded Health Research, Inc. (Roswell Park Division) $830,722 on August 15, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) to assess the respiratory effects of inhaling synthetic coolants used as flavor ingredients in electronic nicotine delivery systems. The project will evaluate pulmonary function and inflammatory effects resulting from inhalation of the synthetic coolants WS-3 and WS-23, which...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Louisville $782,293 on June 10, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Project Grant R01HL185698). The University of Louisville's Office of Research & Innovation will conduct research examining how coolants such as menthol, WS-3, and WS-23 used in electronic cigarettes alter cardiorespiratory and...
- The National Heart Lung and Blood Institute awarded the Regents of the University of Michigan $234,000 on September 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Assistance Listing 93.077) to examine how the duration of electronic nicotine delivery systems (ENDS) use affects cardiopulmonary health outcomes among adults with current or former cigarette smoking histories. The research leverages prospective, nationally...
- The National Heart, Lung, and Blood Institute awarded the University of Maryland, Baltimore $116,625 under Project Grant R03HL188068 on August 15, 2026, to conduct a randomized, within-subject crossover study comparing cardiovascular effects of combustible cigarette smoking and electronic cigarette use in older adults with hypertension. The study enrolls 30 participants aged 50 and older with hypertension and assigns each to two 14-day phases: continued smoking and exclusive use of an authorized...
- The National Heart Lung and Blood Institute awarded the University of Utah $470,606 on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to elucidate the molecular mechanisms of smoking-induced endothelial dysfunction associated with the ALDH2*2 genetic variant. The research employs a multidisciplinary approach integrating stem cell biology, molecular biology, toxicology, vascular physiology, and endothelial mechanobiology to understand how tobacco consumption...
The National Heart, Lung, and Blood Institute awarded the University of Kansas Medical Center Research Institute $774,735 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the effects of ethanol in e-liquids on nicotine delivery, toxicity, and immune response. The project examines how ethanol—present in commercially available e-liquids at concentrations ranging from 1 to 20 percent but not disclosed by manufacturers—alters e-liquid properties and increases harm. Preliminary data indicate that ethanol dose-dependently reduces e-liquid viscosity and boiling point, increases nicotine delivery and vape production per puff, and elevates blood nicotine levels more than threefold in human users. The research also documents that ethanol in e-liquids increases production of potentially toxic chemicals during vaping, including acetaldehyde (a known carcinogen) and 2,2-dimethylbutane (which can cause pneumonitis), and significantly decreases viability of human neutrophils and bronchial epithelial cell cultures. The award funds work performed in Kansas City, Kansas, with a performance period extending through May 31, 2030. The University of Kansas Medical Center Research Institute, a tax-exempt research organization and child entity of the University of Kansas, serves as the recipient. This is a Project Grant assistance type under the NHLBI's Cardiovascular Diseases Research program, which supports basic, translational, clinical, and population sciences research aimed at preventing and treating heart, lung, and blood diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $774.7k | 8/27/26 |