Project Grant R01HL184945
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Health Research, Inc. Roswell Park Division (doing business as Health Research At Roswell Park) $867,448 under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) on August 1, 2026. The recipient will conduct research assessing whether use of fruit-flavored electronic nicotine delivery systems (ENDS) relates to smoking reductions in people who smoke...
- The National Institutes of Health Office of the Director awarded Health Research, Inc. Roswell Park Division (doing business as Health Research At Roswell Park) $1.638 million on September 15, 2025, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) to assess the impact of the substantial equivalence mechanism on cigarette and cigar markets. The recipient will characterize the marketplace for combustible tobacco products by leveraging Nielsen...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Louisville $782,293 on June 10, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Project Grant R01HL185698). The University of Louisville's Office of Research & Innovation will conduct research examining how coolants such as menthol, WS-3, and WS-23 used in electronic cigarettes alter cardiorespiratory and...
- The National Institute on Drug Abuse awarded the University of Kansas Medical Center Research Institute, Inc. $690,741 on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to evaluate the impact of synthetic cooling agent cigarettes on smoking behavior and abuse liability among adult menthol smokers under three regulatory scenarios: no ban, partial ban, and full ban of menthol and cooling agent products. The research examines how regulatory approaches to menthol...
- The National Heart Lung and Blood Institute awarded the Regents of the University of Michigan $234,000 on September 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Assistance Listing 93.077) to examine how the duration of electronic nicotine delivery systems (ENDS) use affects cardiopulmonary health outcomes among adults with current or former cigarette smoking histories. The research leverages prospective, nationally...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $821,294 to The Trustees of Columbia University in the City of New York on September 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Project Grant R01HL179303). The award funds the VAPESCAN study, a longitudinal investigation examining early lung toxicity associated with e-cigarette versus cigarette use in young adults aged 18–50....
- The National Institute of Dental and Craniofacial Research awarded Health Research, Inc. (Roswell Park Division) $347,000 on July 8, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct a large-scale population-based study examining how the use of reduced-exposure nicotine products—electronic nicotine products and oral nicotine pouches—impacts oral health conditions among adults who formerly used combustible or smokeless tobacco in the United States. The research...
- The National Cancer Institute awarded the University of Rochester $583,304 on August 13, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to investigate toxicological assessment of emerging nicotine analogs in electronic nicotine delivery systems (ENDS). The research addresses a substantial knowledge gap regarding the safety profile of novel nicotine analogs, including 6-methyl nicotine and nicotinamide, which manufacturers have introduced to circumvent premarket...
- The National Institute of Environmental Health Sciences awarded $448,686 to the Research Institute At Nationwide Children's Hospital on September 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate how electronic cigarette vapor affects formation of intracellular bacterial communities and recurrence of otitis media caused by nontypeable Haemophilus influenzae. The research examines the molecular mechanisms through which passive exposure to e-cigarette aerosol and...
- The National Heart Lung and Blood Institute awarded $827,439 to Lundquist Institute For Biomedical Innovation At Harbor-UCLA Medical Center on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate mechanisms by which perinatal nicotine vaping exposure dysregulates pulmonary group 2 innate lymphoid cells (ILC2s) and promotes allergic asthma development in offspring. The research employs electronic nicotine delivery system (ENDS) exposure models and...
The National Institutes of Health awarded Health Research, Inc. (Roswell Park Division) $830,722 on August 15, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) to assess the respiratory effects of inhaling synthetic coolants used as flavor ingredients in electronic nicotine delivery systems. The project will evaluate pulmonary function and inflammatory effects resulting from inhalation of the synthetic coolants WS-3 and WS-23, which are increasingly used in "ice"-flavored ENDS products in response to regulatory restrictions on menthol. Although these compounds are recognized as safe for ingestion, their safety has not been evaluated for inhalation, the primary exposure route for ENDS. The research uses an established animal model of chronic inhalation across two specific aims: the first assesses respiratory impact in individuals naive to tobacco products initiating vaping with ENDS containing synthetic coolants compared to the same products without coolants or with menthol, including dose-response effects; the second simulates scenarios in which menthol cigarette smokers switch to vaping ENDS with synthetic coolants, determining changes in pulmonary function and inflammation. The award runs through July 31, 2031. Work is performed in Buffalo, New York. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $830.7k | 8/15/26 |