Project Grant R03HL188185
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Health Research, Inc. Roswell Park Division (doing business as Health Research At Roswell Park) $867,448 under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) on August 1, 2026. The recipient will conduct research assessing whether use of fruit-flavored electronic nicotine delivery systems (ENDS) relates to smoking reductions in people who smoke...
- The National Heart, Lung, and Blood Institute awarded the University of Maryland, Baltimore $116,625 under Project Grant R03HL188068 on August 15, 2026, to conduct a randomized, within-subject crossover study comparing cardiovascular effects of combustible cigarette smoking and electronic cigarette use in older adults with hypertension. The study enrolls 30 participants aged 50 and older with hypertension and assigns each to two 14-day phases: continued smoking and exclusive use of an authorized...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $821,294 to The Trustees of Columbia University in the City of New York on September 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Project Grant R01HL179303). The award funds the VAPESCAN study, a longitudinal investigation examining early lung toxicity associated with e-cigarette versus cigarette use in young adults aged 18–50....
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $718,824 in project grant funding (R01HL188006) on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research into the mechanisms by which electronic cigarette exposure drives vascular injury and atherosclerosis progression through the glutamate N-methyl-D-aspartate receptor (NMDAR) pathway in vascular smooth muscle cells. The research comprises three...
- The National Institutes of Health Office of the Director awarded The Regents of the University of California, San Francisco $1,639,996 on August 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077). The award funds a clinical pharmacology study of oral nicotine pouches (ONPs)—small microfiber sachets filled with purified or synthetic nicotine and typically flavored. The research will examine nicotine exposure and subjective effects from...
- The National Institutes of Health Office of the Director awarded Health Research, Inc. Roswell Park Division (doing business as Health Research At Roswell Park) $1.638 million on September 15, 2025, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) to assess the impact of the substantial equivalence mechanism on cigarette and cigar markets. The recipient will characterize the marketplace for combustible tobacco products by leveraging Nielsen...
- The National Heart, Lung, and Blood Institute awarded The Regents of the University of California, San Francisco $127,168 on April 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to model the effect of apolipoprotein L1 risk variants on cardiovascular disease risk in African American e-cigarette users. The research employs human induced pluripotent stem-cell-derived endothelial cells to investigate how e-cigarettes, with and without menthol, affect endothelial health in...
- The National Institutes of Health awarded Health Research, Inc. (Roswell Park Division) $830,722 on August 15, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) to assess the respiratory effects of inhaling synthetic coolants used as flavor ingredients in electronic nicotine delivery systems. The project will evaluate pulmonary function and inflammatory effects resulting from inhalation of the synthetic coolants WS-3 and WS-23, which...
- The National Institute of Environmental Health Sciences awarded Wayne State University $2,147,837 on June 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate developmental neuronal adaptations induced by gestational e-cigarette vaping using an established pregnant rat model. The research employs state-of-the-art e-cigarette exposure systems with translational inhalation delivery to model human vaping patterns. Preliminary findings demonstrate that gestational e-cigarette...
- The National Cancer Institute awarded the University of Rochester $583,304 on August 13, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to investigate toxicological assessment of emerging nicotine analogs in electronic nicotine delivery systems (ENDS). The research addresses a substantial knowledge gap regarding the safety profile of novel nicotine analogs, including 6-methyl nicotine and nicotinamide, which manufacturers have introduced to circumvent premarket...
The National Heart Lung and Blood Institute awarded the Regents of the University of Michigan $234,000 on September 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Assistance Listing 93.077) to examine how the duration of electronic nicotine delivery systems (ENDS) use affects cardiopulmonary health outcomes among adults with current or former cigarette smoking histories. The research leverages prospective, nationally representative data from the Population Assessment of Tobacco and Health (PATH) Study to assess the association between ENDS use duration and incidence of cardiopulmonary disease, determine whether baseline health status modifies these associations, and evaluate whether changes in cardiopulmonary symptoms among adults switching from cigarettes to ENDS differ according to ENDS use duration. Findings will inform FDA Center for Tobacco Products product assessment, regulation, and evaluation of harm reduction claims, and support targeted public health interventions and policies affecting millions of U.S. adults who currently or formerly smoked cigarettes. Work is performed at the University of Michigan, Ann Arbor, Michigan, with a period of performance from September 1, 2026, through August 31, 2028. The award is a Project Grant, a standard assistance mechanism supporting time-limited research projects. The federal program supports regulatory research under the Family Smoking Prevention and Tobacco Control Act to provide scientific evidence guiding tobacco product regulation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $234.0k | 8/14/26 |