Project Grant R01ES038818
- The National Institute of Environmental Health Sciences awarded Wayne State University $2,147,837 on June 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate developmental neuronal adaptations induced by gestational e-cigarette vaping using an established pregnant rat model. The research employs state-of-the-art e-cigarette exposure systems with translational inhalation delivery to model human vaping patterns. Preliminary findings demonstrate that gestational e-cigarette...
- The National Institutes of Health Office of the Director awarded Wayne State University a cooperative agreement for $1.5 million on August 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to execute the Exposome & Pregnancy-Associated Triggers of Host Immunity and Sex-Dimorphic Outcomes (E-PATHS) program at the C.S. Mott Center for Human Growth and Development. The award funds research examining how sexual dimorphism influences immune adaptation to environmental...
- The National Heart Lung and Blood Institute awarded the Regents of the University of Michigan $234,000 on September 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Assistance Listing 93.077) to examine how the duration of electronic nicotine delivery systems (ENDS) use affects cardiopulmonary health outcomes among adults with current or former cigarette smoking histories. The research leverages prospective, nationally...
- The National Institute of Environmental Health Sciences awarded $448,686 to the Research Institute At Nationwide Children's Hospital on September 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate how electronic cigarette vapor affects formation of intracellular bacterial communities and recurrence of otitis media caused by nontypeable Haemophilus influenzae. The research examines the molecular mechanisms through which passive exposure to e-cigarette aerosol and...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $718,824 in project grant funding (R01HL188006) on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research into the mechanisms by which electronic cigarette exposure drives vascular injury and atherosclerosis progression through the glutamate N-methyl-D-aspartate receptor (NMDAR) pathway in vascular smooth muscle cells. The research comprises three...
- The National Institutes of Health awarded Health Research, Inc. (Roswell Park Division) $830,722 on August 15, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) to assess the respiratory effects of inhaling synthetic coolants used as flavor ingredients in electronic nicotine delivery systems. The project will evaluate pulmonary function and inflammatory effects resulting from inhalation of the synthetic coolants WS-3 and WS-23, which...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $821,294 to The Trustees of Columbia University in the City of New York on September 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Project Grant R01HL179303). The award funds the VAPESCAN study, a longitudinal investigation examining early lung toxicity associated with e-cigarette versus cigarette use in young adults aged 18–50....
- The National Heart, Lung, and Blood Institute awarded the University of Kansas Medical Center Research Institute $774,735 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the effects of ethanol in e-liquids on nicotine delivery, toxicity, and immune response. The project examines how ethanol—present in commercially available e-liquids at concentrations ranging from 1 to 20 percent but not disclosed by manufacturers—alters e-liquid properties...
- The National Heart Lung and Blood Institute awarded $827,439 to Lundquist Institute For Biomedical Innovation At Harbor-UCLA Medical Center on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate mechanisms by which perinatal nicotine vaping exposure dysregulates pulmonary group 2 innate lymphoid cells (ILC2s) and promotes allergic asthma development in offspring. The research employs electronic nicotine delivery system (ENDS) exposure models and...
- The National Institute on Drug Abuse awarded Virginia Commonwealth University $1,182,810 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2026, to identify and characterize non-nicotine compounds in electronic nicotine delivery systems that drive abuse liability through functional activity at nicotinic acetylcholine receptor subtypes. The award funds high-throughput screening methods to comprehensively identify pharmacologically active non-nicotine constituents in...
The National Institute of Environmental Health Sciences awarded Wayne State University $473,313 on September 3, 2026, under the Environmental Health program (CFDA 93.113) to investigate how acid, base, and salt components of electronic cigarettes affect fetal lung development and immune function during pregnancy. The project examines sex-specific impacts of e-cigarette aerosols on neonatal respiratory health using a preclinical pregnant rat model with a state-of-the-art vaping system that replicates human e-cigarette exposure. Preliminary research has shown that freebase nicotine exposure causes sex-specific deficits in innate immune pathways, particularly the neutrophil system, and enhances susceptibility to neonatal viral infection in exposed lungs. The current work expands this scope to include the acidic components found in fourth-generation e-cigarettes, such as benzoic acid used by JUUL, which preliminary data suggest downregulate viral-sensing and type I interferon signaling pathways. Wayne State University's Sponsored Project Administration Division, based in Detroit, Michigan, is the recipient. The award runs through June 30, 2031, with performance at Wayne State's Detroit location. The assistance type is a Project Grant, a standard NIH research mechanism supporting independent investigator-led projects reviewed for scientific merit and technical adequacy by peer study sections and the NIEHS Advisory Council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $473.3k | 9/2/26 |