Project Grant R01HL173344
- The National Institutes of Health's National Heart, Lung, and Blood Institute awarded a $668,783 Project Grant titled "OUTSIDE-IN" MODEL OF CARDIAC PACEMAKING: EXTRACELLULAR MEDIATED AUTOMATICITY" to the University of North Carolina at Chapel Hill. The grant, which runs from July 15, 2025 to April 30, 2029, supports research to understand the molecular pathophysiology and biophysical processes underlying electrical impulse generation in the heart's sinoatrial node, the natural...
- This $125,703 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research investigating the role of the SYNE1-giant gene in atrial cardiomyopathy. The principal investigator is conducting a comprehensive study to understand the mechanisms by which mutations in the SYNE1 gene, which encodes mechanosensitive proteins in the nuclear envelope, contribute to the development of atrial fibrillation and sinus node dysfunction....
- This $568,177 federal Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on how centrioles, the core structures of centrosomes, control mammalian development. The University of California, San Francisco (UCSF) is the primary awardee and will leverage advanced techniques like centrosome affinity capture mass spectrometry and pan-expansion microscopy to investigate how centriole defects...
- This $673,512 Project Grant awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by the University of California, San Francisco (UCSF) to investigate the neural mechanisms underlying breathing rhythms. The project aims to determine whether the subconscious breathing rhythm arises from an autonomous oscillator or reciprocal inhibition between key neuronal populations in the brainstem. UCSF will use advanced mouse...
- This Project Grant award for $727,710.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to advance understanding of the mechanisms driving arrhythmogenic cardiomyopathy, a genetic heart disease that can cause sudden death in young people. The award supports research at the University of California, San Diego (UCSD) to develop preclinical mouse models exhibiting inflammation and T-cell mediated immune responses as key drivers of this...
- The federal Project Grant award of $507,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to develop an automated system that integrates micro-electromechanical sensors, automation, and machine vision to simultaneously measure electrophysiological properties and contractile forces in single human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). This innovative system is expected to significantly reduce measurement time...
- The University of California, San Diego (UCSD) was awarded a $788,513 project grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to study the mechanisms underlying the maintenance of cardiac chamber identity in zebrafish. The research aims to elucidate the genetic pathways that reinforce ventricular cardiomyocyte identity, as ventricular myocardium harbors considerable plasticity and can transform to acquire atrial traits under certain...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research to develop a biomolecular-based technology that can locally deliver photocurrents to cardiomyocytes. The $350,112 project, running from August 1, 2025 to July 31, 2027, aims to create free-standing nanostructures that are photocurrent-generating and cell-interacting, serving as phototransducer cardiac biomaterials. The research being conducted at the...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $540,856 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) on Dec 15, 2024. The goal of this 4-year project is to identify transcriptional regulators that control endocardial-specific gene expression and valve development, as well as understand the regulation and function of the SLC16A2 gene during heart injury and regeneration. The...
- This $761,152 project grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of California, San Diego (UCSD) to investigate the gene regulatory mechanisms controlling the expression of cardiac myosin heavy chain proteins. The goal is to understand how shifts in the ratio of the MYH6 and MYH7 isoforms impact cardiac contractility, which is critical for heart function under both normal and disease...
This $556,295 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance scientific understanding of cardiac pacemaking and sinus node dysfunction (SND) through research on "conditional pacemaker cells" within distinct specialized pacemaker cell subpopulations. The project will leverage advanced optical mapping technology to directly visualize pacemaking activities within these specialized cell subpopulations and integrate organ-wide functionality, innervation, and single-cell transcriptomics to better characterize the role of these previously unrecognized "conditional pacemaker cells" in SND pathology. The ultimate goal is to develop more effective therapeutic strategies to address the significant cardiovascular morbidity and mortality associated with SND. The award period runs from August 1, 2025 through May 31, 2030 and is being provided to the University of California, San Francisco as the primary awardee.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $556.3k | 7/31/25 |