Project Grant R21NS142546
- Federal Grant Award Summary RTI International received a $603,406 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective May 9, 2025, through April 30, 2027. The award supports development of GPR139 (G protein-coupled receptor 139) antagonist compounds for pain treatment. The project addresses the critical public health challenge of...
- Federal Grant Award Summary Research Triangle Institute (RTI International) received a $547,846 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2027. The award supports research focused on the optimization and characterization of small molecule GPR17 (G protein-coupled receptor 17) antagonists for...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $407,113 to the University of California, Irvine on August 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support development of novel KV7 channel modulators for pain therapy. This R21 exploratory research grant, which concludes July 31, 2027, will establish an empirical foundation for developing therapies targeting...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of North Carolina at Chapel Hill a $222,758 Project Grant on August 7, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research through July 31, 2027. The award funds a comprehensive neuroscience investigation aimed at delineating how different molecularly defined dorsal root ganglia (DRG) neuron types contribute to pain representation...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded a $4.04 million Project Grant to the University of Texas at Dallas for a three-year initiative (September 1, 2025 through August 31, 2028) to identify and validate therapeutic targets for chronic pain treatment. The project leverages a CRISPR-based functional genomic screening platform developed by collaborating researchers at the University of Sydney and an extensive human dorsal root ganglion...
- This $1,511,970 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the development of selective GPR34 antagonists for the treatment of neuropathic pain. The award aims to identify CNS-active GPR34 hits that can be further developed into novel GPR34 antagonists as potential drug candidates for neuropathic pain. Key products and services include: 1) Synthesis and testing of novel...
- Federal Project Grant Summary Function Therapeutics Inc. received a $499,863 Project Grant award from the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 11, 2025, with a completion date of August 31, 2027. This grant supports research and development of parmodulins, a novel class of small-molecule therapeutics designed to treat neuropathic pain without abuse potential. The project involves synthesizing and...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of California, San Francisco a $1,179,715 Project Grant on March 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative, scheduled for completion by January 31, 2034, focuses on elucidating the fundamental mechanisms underlying nociception—the process by which nerve fibers...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $226,530 to The Regents of the University of California, San Francisco under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) effective August 1, 2025, through July 31, 2030. This K23 Career Development Award supports research investigating precision medicine approaches to chronic neuropathic pain through non-invasive...
- Federal Project Grant Award Summary The University of Pittsburgh received a $620,504 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded February 11, 2026, with completion targeted for November 30, 2030. This award supports fundamental neuroscience research investigating how the brain prioritizes competing survival needs and suppresses chronic...
Research Triangle Institute (RTI International) received a $230,562 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded April 17, 2026, with completion targeted for March 31, 2028. The project, conducted in Durham, North Carolina, focuses on the development of Neuromedin Receptor 2 (NMUR2) antagonists as novel therapeutic agents for chronic pain management. Under this award, RTI International will establish comprehensive structure-activity relationship (SAR) data for two chemical series of NMUR2 antagonists, optimizing their potency, selectivity, and drug-like properties. The deliverables include SAR findings for compound optimization, early-stage absorption, distribution, metabolism, and excretion (ADME) data, and pharmacokinetic information. These outputs are intended to support the development of NMUR2-targeting tool compounds and drug candidates that could provide safer alternatives to opioid-based pain management, addressing a critical public health need for chronic pain treatment with reduced risk of dependency and tolerance.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $230.6k | 4/17/26 |