Project Grant R01HD122731
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $149,190 on March 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.HDR) to support research on the regulation and functions of DNA polymerases in the Drosophila male germline stem cell lineage. The research investigates asymmetric cell division in germline stem cells, focusing on how differential expression of DNA polymerase catalytic subunits (POLA, POLD,...
- The National Institute of Child Health and Human Development awarded $668,485 to the University of California, San Diego on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate DNA repair mechanisms in hypoxia-induced placental genomic instability. The research examines increased genomic instability in placental villous tissue and trophoblast stem cells associated with maternal vascular malperfusion, a pattern of placental...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $198,728 on February 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of novel RNA binding proteins during dauer in C. elegans. The project characterizes how microRNA pathway regulation transitions from supporting developmental gene expression to enabling stress-adaptive gene expression when the nematode enters the dauer...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services, awarded The Johns Hopkins University $133,432 on April 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the neurometabolic trajectory of the developing brain. The recipient will use magnetic resonance spectroscopy and imaging techniques to map multiple neurometabolites simultaneously in infants and young children,...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $297,252 on September 21, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impact of chromosome 21 dosage on the placenta secretome and neurodevelopment in Down syndrome. The research examines whether placental abnormalities contribute to altered cortical development in individuals with Down syndrome (trisomy 21). The project uses...
- The National Institute of Child Health and Human Development awarded Duke University $581,258 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate transposable elements as mechano-response enhancer elements regulating human embryonic stem cell fate. The research examines how mechanical forces regulate transposable element sequences that control gene expression and pluripotent stem cell differentiation. The project tests three...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services, awarded The Johns Hopkins University $1,176,983 on September 12, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a cluster randomized trial examining the relationship between periodontal disease and outcomes in small vulnerable newborns. The award addresses neonatal mortality among preterm and small-for-gestational-age infants,...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- Federal Project Grant Award Summary The Johns Hopkins University received a $426,375 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded September 26, 2025, with a completion date of August 31, 2027. The award funds development of stable CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) systems in zebrafish utilizing phic31 attP safe harbor integration...
- The National Institute of Child Health and Human Development awarded Emory University $100,228 on December 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research into developmental and cell-type-specific histone gene expression patterns through May 31, 2029. The research traces histone transcripts to their gene and locus of origin to determine how identical histone genes are expressed throughout development and maintain proper...
The National Institute of Child Health and Human Development awarded The Johns Hopkins University $635,308 on August 24, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to investigate the long-term epigenetic consequences of DNA damage during embryonic development. The research examines how double-strand DNA breaks during gastrulation and organogenesis trigger genome integrity pathways that establish long-term silencing around damaged sites through inactivating epigenetic marks. The project will define the developmental window susceptible to DNA break-induced silencing using lineage barcoding systems, determine the size of the silencing footprint across diverse genomic contexts through genome-wide characterization of chromatin accessibility and gene expression, and elucidate the molecular pathways underlying these epigenetic responses. The central hypothesis posits that DNA damage during embryogenesis can result in clonal congenital disorders by causing somatic epigenetic lesions even when DNA sequence remains intact. The award runs from August 24, 2026, through April 30, 2031, with performance at Johns Hopkins University in Baltimore, Maryland. The research is structured as a Project Grant, the standard assistance type for NIH extramural research awards to individual institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $635.3k | 8/25/26 |