Project Grant R21HD120879
- Federal Project Grant Award Summary The Johns Hopkins University received a $336,738 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 6, 2025, with a completion date of July 31, 2027. This award supports research to develop and refine an acute kidney injury (AKI) multimarker panel using blood-based and urine-based biomarkers for pediatric patients...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development awarded The Johns Hopkins University a $1.46 million Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) effective September 15, 2025 through August 31, 2027. The award funds the Care, Housing Assistance, Medicaid, and Perinatal (CHAMP) Health Outcomes Study, which investigates the association between federal housing assistance and perinatal and infant...
- Federal Project Grant Award Summary The Johns Hopkins University received a $318,750 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective March 15, 2025 through February 28, 2027. The project, "Measuring Postpartum Pregnancy Risk to Improve Healthy Birth Intervals," will deliver longitudinal research utilizing two population-based cohorts of...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $635,308 on August 24, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to investigate the long-term epigenetic consequences of DNA damage during embryonic development. The research examines how double-strand DNA breaks during gastrulation and organogenesis trigger genome integrity pathways that establish long-term silencing...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $198,728 on February 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of novel RNA binding proteins during dauer in C. elegans. The project characterizes how microRNA pathway regulation transitions from supporting developmental gene expression to enabling stress-adaptive gene expression when the nematode enters the dauer...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded The Johns Hopkins University a $434,068 Project Grant effective September 15, 2025 through August 31, 2027, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The VITAL (Verbal Autopsy Through Integrated Language Analysis) project addresses critical gaps in global mortality surveillance by developing innovative natural language processing (NLP) and...
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
- Federal Project Grant Award Summary The Johns Hopkins University received a $900,000 Project Grant from the National Science Foundation's Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), effective September 1, 2025 through August 31, 2028. This award supports research examining the mechanistic roles of hyper-divergent genomic regions in gene-by-environment interactions using nematode species as model organisms. The research employs advanced genomics...
- The National Institute of Child Health and Human Development awarded Cincinnati Children's Hospital Medical Center $445,500 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.HDR) to develop and optimize a compact CRISPR activation system using the miniature Cas12f nuclease within an adeno-associated virus (AAV) vector for modulating lung vascular enhancers. The project targets regulatory DNA elements that control cell- and...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded $429,000 in Project Grant funding to the University of Colorado-Denver for research conducted under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award was obligated on August 6, 2025, with a project completion date of July 31, 2027. This R21 mechanism grant supports research utilizing induced pluripotent stem cell (iPSC)...
Federal Project Grant Award Summary The Johns Hopkins University received a $426,375 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded September 26, 2025, with a completion date of August 31, 2027. The award funds development of stable CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) systems in zebrafish utilizing phic31 attP safe harbor integration sites. The deliverables include establishment and validation of codon-optimized molecular constructs (catalytically inactive Cas9 fused to KRAB and MeCP2 inactivating domains for CRISPRi, and VP64 activator domain for CRISPRa) that enable systematic modulation of gene function without permanent DNA modifications. The project team will translate proof-of-concept RNA injection methodologies into stable transgenic systems to overcome the time-limited effects of transient approaches. This research addresses a critical gap in zebrafish functional genomics by providing reliable, heritable tools for loss-of-function and gain-of-function studies. The project builds on preliminary work demonstrating CRISPRi/a efficacy in modulating melanocyte differentiation genes and energy homeostasis pathways, with validated biological endpoints including pigmentation and body length phenotypes. The stable integration platform will expand zebrafish capacity for investigating gene function in both normal development and disease contexts, directly supporting NICHD's mission in understanding human development and health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $426.4k | 9/26/25 |