Project Grant R01HD122847
- The National Institute of Child Health and Human Development awarded Duke University $694,448 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research analyzing local and global responses in the placenta syncytiotrophoblast. The research investigates the multinucleated syncytiotrophoblast, a giant single cell that separates maternal and fetal vasculature during pregnancy and performs critical functions including nutrient...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $153,560 on December 1, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865) to investigate gene regulatory mechanisms driving totipotency induction in human stem cells. The research examines how RNA splicing dysfunction alters early human development through integrative transcriptomic, epigenomic, and proteomic profiling. The work focuses on...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $230,388 on January 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the effects of rare damaging mutations in transforming growth factor-beta (TGFB) latent complex proteins found in preeclamptic placentas. The research examines how mutations in fibronectin 1 (FN1) and latent transforming growth factor beta binding protein 1...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development, an office of the Department of Health and Human Services, awarded $600,016 to the University of California, San Diego on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate extracellular vesicles as mediators of kidney damage in preeclampsia. The research employs a three-dimensional microfluidic human proximal tubule kidney-on-a-chip model to study how placental and serum...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $635,308 on August 24, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to investigate the long-term epigenetic consequences of DNA damage during embryonic development. The research examines how double-strand DNA breaks during gastrulation and organogenesis trigger genome integrity pathways that establish long-term silencing...
- The National Institute of Child Health and Human Development awarded the University of Texas Health Science Center at Houston $688,009 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate trophoblast differentiation and placental aging. The award funds research testing the hypothesis that precocious trophoblast differentiation leads to exhaustion of the trophoblast stem cell pool, triggering premature placental aging and...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded $429,000 in Project Grant funding to the University of Colorado-Denver for research conducted under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award was obligated on August 6, 2025, with a project completion date of July 31, 2027. This R21 mechanism grant supports research utilizing induced pluripotent stem cell (iPSC)...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $456,500 to The University of Texas Southwestern Medical Center on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds molecular characterization of human pregnancy-induced cervical epithelium through two research aims. First, the recipient will apply single-cell and spatial...
- The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
The National Institute of Child Health and Human Development awarded $668,485 to the University of California, San Diego on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate DNA repair mechanisms in hypoxia-induced placental genomic instability. The research examines increased genomic instability in placental villous tissue and trophoblast stem cells associated with maternal vascular malperfusion, a pattern of placental injury linked to maternal hypertensive disorders such as preeclampsia and fetal growth restriction. The study builds on preliminary data revealing oxidative DNA damage and reduced DNA repair activity in affected trophoblasts, including rare damaging somatic mutations in senataxin, a helicase that resolves RNA-DNA hybrids and protects genomic integrity under hypoxia-reoxygenation stress. The research uses whole genome sequencing, bulk RNA sequencing, and patient-derived induced pluripotent stem cells converted to trophoblast stem cells to elucidate the mechanisms underlying genomic instability in maternal vascular malperfusion and develop a mechanistic understanding of how DNA repair deficiency drives this pathology. Performance occurs at UC San Diego's La Jolla, California campus. The award period extends from September 1, 2026, through May 31, 2031. This is a Project Grant, the standard assistance type for NIH research awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $668.5k | 8/24/26 |