This federal Project Grant award of $794,894 from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) supports research to characterize key immune pathways that interact with hormonal responses in endometriosis. The primary awardee, the University of Texas Health Science Center at San Antonio, will utilize existing research infrastructure to collect endometriosis lesions, eutopic endometrium, peritoneal fluid, and peripheral...
This Project Grant award for $233,250.00, provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to identify the mechanisms underlying endometriosis pain and changes in pain after lesion removal surgery. The key objectives of the research are to examine central mechanisms of inhibitory pain modulation capabilities and systemic estrogen levels, as well as peripheral...
This $2,045,782 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports the development of ENDO-205, a novel, non-hormonal therapeutic for endometriosis. Endometriosis is a prevalent and debilitating disease affecting approximately 10% of women worldwide, with no current cure. The grant enables the awardee, Endomet Biosciences, Inc., to...
This $643,049 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop a physiomimetic (tissue-engineered) model of the endometrioma lesion microenvironment. The project's objective is to investigate the processes responsible for the initiation and invasion of endometriosis lesions, which could inform the design of effective therapeutic strategies....
This $461,320 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will fund a study on risk factors and consequences of endometriosis among Black women. The primary awardee, the Fred Hutchinson Cancer Center, will utilize data from the Black Women's Health Study to investigate established endometriosis risk factors like parity, age at menarche, and body size, as well as the association...
This $624,000 Project Grant was awarded on August 1, 2024 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund a 2-year research project at the University of Michigan to investigate the impact of obesity and adiposity on the human endometrium. The key objectives are to: 1) use single-nuclear RNA sequencing to comprehensively understand how pathological adiposity...
This $675,852 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to investigate the pathophysiology of adenomyosis, a common uterine disorder, at the single-cell level. The primary goal is to use advanced single-cell analytics and drug discovery approaches to identify novel or repurposed drugs that can reverse the adenomyosis phenotype and alleviate associated symptoms. The work involves creating a detailed...
This $509,220 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to validate novel, non-hormonal, and non-opioid approaches for treating endometriosis-associated pain. The key products and services to be delivered through this award include: Identifying the inflammatory mediators and signaling pathways activated in macrophages upon stimulation by the neuropeptide CGRP, which...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $250,206.00 to the University of Arizona to conduct research on the uterotubal junction (UTJ) and develop a minimally invasive endoscope for early detection of endometriosis. The key objectives are to: 1) Compare the functional and morphological characteristics of the UTJ in women with and without...
This $660,773 Project Grant award, issued by the National Institute of Child Health and Human Development (CFDA 93.865 Child Health and Human Development Extramural Research program), will support research at the University of Michigan to assess the impact of obesity on the endometrium (uterine lining) and the reversibility of these changes with significant weight loss following bariatric surgery. The project aims to characterize the molecular, cellular, and functional alterations to the...