This Project Grant award, totaling $752,491, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research at Kent State University and Colorado State University to investigate the neural circuits and mechanisms mediating pulsatile and surge secretion of gonadotropin-releasing hormone (GnRH), which is critical for regulating fertility in female mammals. The...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $624,809 to Brigham & Women's Hospital Inc. to investigate the role of dopamine regulation in controlling the activity of KNDY neurons, which are critical for regulating reproductive function. The research aims to characterize how disruptions in the TIDA neuron-KNDY neuron network contribute to...
This Project Grant award of $440,000 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research on the role of SMAD5 signaling in polycystic ovary syndrome (PCOS) at Baylor College of Medicine. The study aims to conduct a broad biochemical analysis to determine how a newly discovered SMAD variant alters canonical and non-canonical SMAD properties, and identify the causal...
This Project Grant award, valued at $232,500.00, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research to investigate the role of circular RNA (circRNA) in ovarian follicular development and fertility. The project will examine the effect of the KHDRBS1 protein on circRNA biogenesis and its impact on fertility using a granulosa cell-specific KHDRBS1 knockout...
This Project Grant award of $1,040,056 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to elucidate the role of leukocytes and their derived cytokines in the ovulatory process in humans. The study aims to characterize the expression profile of these cytokines and their receptors in dominant follicles throughout the ovulatory period, and to determine the impact of...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $178,000 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to investigate the effects of maternal genetic risk factors for polycystic ovary syndrome (PCOS) on birth and childhood outcomes in offspring. The project aims to leverage recent advances in...
This federal Project Grant award of $335,862 was provided by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), to the Regents of the University of Michigan. The award will support research led by Dr. Danielle Porter to study the role of the melanocortin-3 receptor (MC3R) in regulating the hypothalamic-pituitary-gonadal (HPG) axis and its implications for reproductive disorders. The...
This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under CFDA program 93.865 Child Health and Human Development Extramural Research, will fund a multi-disciplinary research effort to uncover novel insights into endocervical mucus secretion. The primary goal is to understand how female sex hormones regulate the biophysical properties of endocervical mucus in order to inform the development of novel, non-hormonal therapeutics for...
The National Institute of Child Health and Human Development (NICHD) awarded a $147,486 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The grant, which runs from September 1, 2025 to August 31, 2028, will support research investigating the role of the protein KIF2C in regulating the microtubule cytoskeleton during the...
This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $108,512 to the University of Illinois to investigate the role of salt-inducible kinase 3 (SIK3) in regulating fertility through ovarian granulosa cell function. The research aims to elucidate the upstream regulation, downstream targets, and metabolic effects of SIK3 in granulosa cell differentiation. Specifically,...