This $595,858 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research conducted by the Regents of the University of Michigan to investigate the role of hypothalamic SH2B1 neurocircuits and SH2B1 signal transduction pathways in obesity and metabolic disease. The research aims to determine how SH2B1-expressing neurons in the paraventricular...
This Project Grant award from the National Institute of Mental Health (NIMH) under the CFDA 93.242 Mental Health Research Grants program provides $667,250 to Michigan State University to conduct research on the hormonal programming of the mesocorticolimbic dopamine circuit during adolescent development. The research aims to: 1) Determine how gonadal hormones program the adolescent outgrowth of dopaminergic axons from the nucleus accumbens to the medial prefrontal cortex, and 2) Establish...
The federal Project Grant award R21HD115119, totaling $531,174, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to develop and test novel dual agonist therapies targeting the melanocortin and gut-peptide receptors for the treatment of childhood obesity. The research plan includes two specific aims: 1) fully characterizing and optimizing a GLP-1R/MC4R dual...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $146,922 to Oregon Health & Science University (OHSU) from September 1, 2025 to April 8, 2028. The project aims to investigate the mechanisms by which misalignment of light and food cues can disrupt the normal timing of the luteinizing hormone (LH) surge and ovulation, which is commonly...
The federal Project Grant award R01HD118655, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research on the dopaminergic regulation of KNDY neurons and its implications for GnRH pulses and polycystic ovary syndrome (PCOS). The $624,809 award, with a project period from June 1, 2025 to March 31, 2030, aims to identify and characterize the neuronal population that is...
This $162,512 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to examine how the circadian clock influences reproductive behavior and sexual drive in mice. The project, conducted by the Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA, aims to determine if the timing of peak sexual behavior between males and females impacts...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 Mental Health Research Grants, provides $178,087 to Michigan State University to study the regulation of hippocampal neuronal excitability by androgen receptors and its implications for understanding sex differences in major depressive disorder. The key objectives of this research project are to: 1) Determine the signaling mechanisms by which androgen receptors regulate ventral...
This $660,773 Project Grant award, issued by the National Institute of Child Health and Human Development (CFDA 93.865 Child Health and Human Development Extramural Research program), will support research at the University of Michigan to assess the impact of obesity on the endometrium (uterine lining) and the reversibility of these changes with significant weight loss following bariatric surgery. The project aims to characterize the molecular, cellular, and functional alterations to the...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $156,000 to the Regents of the University of Michigan from August 1, 2024 to July 31, 2026 to enhance and archive genomic data from the Panel Study of Income Dynamics (PSID) Child Development Supplement. The key products and services to be delivered under this award include: 1) Developing essential...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to develop and validate a new measure, the Patient-Centeredness of Peripartum Birth Control Counseling (PPBC) measure, to assess the patient experience of peripartum contraceptive care. The $258,301 award to the Regents of the University of Michigan will support adapting an existing patient-reported outcome measure to the...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $335,862 to the Regents of the University of Michigan to investigate the role of the melanocortin-3 receptor (MC3R) in regulating the hypothalamic-pituitary-gonadal (HPG) axis. The research aims to study the neuroendocrine function of MC3R in the physiology and pathophysiology of HPG axis control, including potential sex differences. The project will provide the principal investigator, Dr. Danielle Porter, with additional training in metabolic physiology, pharmacology, and whole brain imaging techniques to enable her to initiate an independent research program on MC3R neural circuits as therapeutic targets for disorders at the intersection of reproduction and metabolism. The award period runs from Aug 1, 2024 to Jul 31, 2025.