Project Grant R01HD114782

Award Date 4/1/25
Completion Date 12/31/29
Dollars Obligated $752K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Kent, OH 44242, USA
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The purpose of this award is to support research on the neural circuits mediating pulsatile and surge secretion of gonadotropin-releasing hormone (GnRH), which is critically important for female fertility. The research will focus on testing the hypothesis that specific subpopulations of neurons in the arcuate nucleus of the hypothalamus, including those expressing Kiss1r, play a key role in driving episodic and surge GnRH secretion. This research in sheep, an animal model closely resembling human reproductive physiology, aims to further refine understanding of the neural systems responsible for regulating GnRH release, with potential clinical relevance for reproductive disorders like polycystic ovarian syndrome.

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