This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, totaling $665,122.00, supports research to understand the role of the glucocorticoid receptor in the ovary. The research aims to determine the physiological significance of the glucocorticoid receptor and identify its transcriptomic, genomic, and functional changes necessary for successful ovulation...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $154,000 to The University of Kentucky Research Foundation to investigate the role of long non-coding RNAs (lncRNAs) in the ovulatory process. The research aims to identify the top 5 most highly LH/HCG-regulated lncRNAs and characterize their function in the ovary, particularly the role of the lncRNA GM12648 in regulating genes...
This $426,250 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, aims to investigate the role of circular RNA (circRNA) in ovarian follicular development and fertility. The key objectives are to: 1) Examine the effect of granulosa cell-specific KHDRBS1 loss on LH-regulated circRNA biogenesis and fertility, and 2) Elucidate the molecular mechanisms and functional impact of...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $108,512 to the University of Illinois to investigate the mechanisms by which the protein Salt-Inducible Kinase 3 (SIK3) regulates fertility. The research aims to elucidate SIK3's upstream regulation, downstream targets, and role in the metabolism of ovarian granulosa cells,...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $743,287 to Oregon Health & Science University (OHSU) to conduct research on endocervical mucus secretion. The goal is to uncover the cells and pathways affected by female sex hormones that regulate mucus biophysical properties, with the long-term aim of developing novel,...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research at King's College London to investigate how follicle-stimulating hormone (FSH) glycoforms modulate the function of the FSH receptor (FSHR) in the aging ovary. The $739,702 award, effective August 19, 2024 through May 31, 2029, aims to elucidate the distinct roles...
This $900,441 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research at Brown University to uncover the developmental and molecular mechanisms underlying the establishment and maintenance of the ovarian follicle reserve in mice. The goal is to better understand, diagnose, and potentially treat primary ovarian insufficiency (POI) and female...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will provide $232,308 to Magee-Womens Research Institute and Foundation to elucidate the role of the hyaluronan matrices on the establishment and maintenance of the ovarian reserve and reproductive longevity. The research aims to test the hypothesis that the stromal microenvironment of the fetal ovary,...
This federal Project Grant award, valued at $643,049.00 and issued by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 Child Health and Human Development Extramural Research, will fund the development of a physiomimetic model of the endometrioma lesion microenvironment at the University of Illinois. The research aims to investigate the multicellular interactions and tissue tropism that drive the initiation and invasion of endometriotic lesions, which...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand how calcium triggers the transition from a mature egg cell to an embryo. The $335,955 award to Cornell University, effective December 9, 2024, will fund a 5-year investigation into the post-translational mechanisms that mediate this critical...
The University of Kentucky Research Foundation was awarded a $1,040,056 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant, awarded on August 22, 2024, supports a research study to elucidate the role of leukocytes and their derived cytokines in facilitating ovulation and luteinization in the human ovary. The study aims to characterize the expression profile of these cytokines and their receptors in dominant follicles throughout the ovulatory period, and to determine the impact of these leukocyte-derived cytokines on granulosa cell function and the ovulatory process. The research has the potential to provide insights into the development of innovative therapeutic strategies for improving women's reproductive health and fertility.