Project Grant R21HD110932

Award Date 8/22/24
Completion Date 7/31/26
Dollars Obligated $426K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Kansas City, KS 66160, USA
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This $426,250 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, aims to investigate the role of circular RNA (circRNA) in ovarian follicular development and fertility.

The key objectives are to: 1) Examine the effect of granulosa cell-specific KHDRBS1 loss on LH-regulated circRNA biogenesis and fertility, and 2) Elucidate the molecular mechanisms and functional impact of LH-regulated circRNA on periovulatory follicular events such as cumulus expansion, oocyte maturation, ovulation, and luteinization. The research will be conducted by the University of Kansas Medical Center Research Institute, Inc. over the award period from August 2024 to July 2026.

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