The National Institute of Child Health and Human Development (NICHD) awarded a $250,500 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Cedars-Sinai Medical Center to study the mechanisms by which impaired renal reserve leads to an increased risk of preeclampsia during pregnancy. The research aims to understand how a deficiency in the metabolite L-kynurenine, critical for nicotinamide adenine dinucleotide synthesis, contributes to abnormal placentation...
This federal Project Grant award for $232,500.00 was awarded on August 13, 2024 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund research led by Wake Forest University Health Sciences (WFUHS) to investigate the neuroprotective actions of the apelinergic axis (consisting of apelin, elabela, and the apelin receptor) on the long-term cerebrovascular consequences of...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $869,696 to Vanderbilt University Medical Center (VUMC) to investigate the link between preeclampsia and the development of heart failure with preserved ejection fraction (HFpEF) in women.
The key objectives are to: 1) Measure the relationship between post-partum subclinical left ventricular diastolic dysfunction and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $2,559,308 to Pennsylvania State University to study the impact of severe pre-eclampsia on heart function in women from diverse racial backgrounds. Key objectives include:
Characterizing the cardiomyopathic genetic profile of women with severe pre-eclampsia across different racial cohorts and assessing the potential impact of...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $485,925 to the University of Massachusetts Boston to develop novel antioxidant compounds for treating preeclampsia, a life-threatening pregnancy complication. The primary goal is to design and synthesize cationic hydrazone antioxidants that can target mitochondria to reduce oxidative stress, improve...
The National Institute of Child Health and Human Development (NICHD) awarded a $1,435,204 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Texas Medical Branch at Galveston (UTMB) to conduct research on preeclampsia. The goal is to assess the efficacy of the disaccharides trehalose and lactotrehalose in preventing and treating preeclampsia, a leading cause of maternal and fetal morbidity and mortality. The 5-year grant will support...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $456,251 to Colorado State University to conduct research on the mechanisms by which maternal obesity and inflammation contribute to pregnancy complications such as preeclampsia.
The overarching goal is to test the hypothesis that pro-inflammatory factors produced by maternal adipose tissue reduce...
This $1,829,617 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support a research project at the University of California, San Diego (UCSD) to study the cellular and molecular mechanisms underlying placental defects associated with early-onset preeclampsia.
The key objectives of the 5-year project are to: 1) Identify optimal stem cell-based methods to...
This National Institutes of Health (NIH) National Institute of Child Health and Human Development (NICHD) federal Project Grant award under CFDA 93.865 (Child Health and Human Development Extramural Research) will provide $493,409 to Oregon Health & Science University (OHSU) from September 16, 2024 to August 31, 2029 to investigate the role of the renin-angiotensin system, specifically the ACE2 protein, in placental development and fetal growth during pregnancy. The project aims to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $996,050 to Tulane University to investigate the role of T cell-derived oxidative stress in the development of maternal syndrome associated with preeclampsia. The research aims to: 1) test the hypothesis that T cell-derived reactive oxygen species (ROS) through the NOX2 pathway causes maternal syndrome in a rat model of...