This Project Grant award of $1,829,617 from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 Child Health and Human Development Extramural Research, aims to develop stem cell-based models to study placental defects associated with early-onset preeclampsia. The 5-year project, commencing on July 1, 2024, will pursue three key objectives: 1) Identify optimal stem cell methods to model abnormal trophoblast differentiation in preeclampsia placentas, 2)...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $717,285 to conduct a large-scale investigation of the vaginal ecosystem in preeclampsia. The primary awardee, The Trustees of Columbia University, will lead a team to perform longitudinal metagenomic and metabolomic profiling of approximately 4,200 vaginal samples from 389 pregnancies with severe...
This $148,880 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research on the role of B cells and autoantibodies in preeclampsia and their long-term effects on the offspring. The research aims to: Test the hypothesis that B cells from women with preeclampsia produce autoantibodies that cause hypertension, cerebrovascular dysfunction, and cognitive...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $232,500.00 to Wake Forest University Health Sciences (WFUHS) to conduct research on the neuroprotective actions of the apelinergic axis (apelin, elabela, and apelin receptor) in relation to the long-term cerebrovascular consequences of preeclampsia. The research aims to improve understanding...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $485,925 to the University of Massachusetts Boston to develop novel antioxidant compounds for treating preeclampsia, a life-threatening pregnancy complication. The primary goal is to design and synthesize cationic hydrazone antioxidants that can target mitochondria to reduce oxidative stress, improve...
This $1,888,904 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to reduce the risk of chronic hypertension and improve vascular function following preeclampsia. The principal awardee, The Medical College of Wisconsin, Inc., is conducting this 5-year research project in Milwaukee, WI. The project aims to investigate the mechanisms behind the increased risk of...
The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
The federal Project Grant award R21HD111905, with a total funding of $234,000.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The primary awardee, The Regents of the University of Colorado (University of Colorado-Denver), will conduct research to investigate the functional importance of a novel NF-kB genetic variant (rs230511) and its role in the development of...
This Project Grant award from the Department of Health and Human Services National Institutes of Health National Institute of Child Health and Human Development provides $769,916 to Emergent Biotechnologies LLC for research into a novel therapy for preeclampsia. The funding supports Phase 1 of developing and characterizing a handle region peptide as an innovative treatment for preeclampsia under the Child Health and Human Development Extramural Research program (CFDA 93.865). Phase 1 work will...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $456,251 to Colorado State University from August 1, 2024 to May 31, 2029 to conduct research on the mechanisms linking maternal obesity and inflammation to abnormal placental development and preeclampsia. The overarching goal is to test the hypothesis that pro-inflammatory mediators produced by...