The National Institute of Child Health and Human Development (NICHD) awarded Oregon Health & Science University (OHSU) a $493,409 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) on Sep 16, 2024 to fund a 5-year research project titled "INVESTIGATION OF THE RENIN-ANGIOTENSIN SYSTEM AT THE MATERNAL-FETAL INTERFACE." The project aims to test the hypothesis that the enzyme ACE2 plays a key role in modulating normal placental development and fetal growth at the maternal-fetal interface, independent of the maternal circulation and kidney. The research will involve in-depth morphological phenotyping, novel protein analyses, and blood pressure monitoring in mice to elucidate the function of the renin-angiotensin system in the placenta and decidua. The project will also analyze gene expression, protein abundance, and localization of the renin-angiotensin system in rhesus macaque placentas, which are more structurally similar to humans, to improve understanding of these processes in human pregnancy. The findings could provide insights into the causes of pregnancy loss and complications, potentially leading to advancements in maternal-fetal medicine.
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