This National Heart, Lung, and Blood Institute (NHLBI) Project Grant award under the Cardiovascular Diseases Research program (CFDA 93.837) is funding a $869,696 study by Vanderbilt University Medical Center (VUMC) to investigate the link between preeclampsia and the development of heart failure with preserved ejection fraction (HFpEF). The 5-year study will leverage VUMC's expertise in cardio-obstetrics research to recruit and assess a diverse cohort of 500 women, including 25% Black participants, to measure the relationship between preeclampsia, subclinical left ventricular diastolic dysfunction, and emerging cardiovascular risk factors. The researchers aim to define early hemodynamic and biomarker profiles associated with increased HFpEF risk in this population, which could inform future interventional studies to mitigate disease progression. This award supports VUMC's broader efforts to advance understanding of cardiovascular disease development in women, particularly those with pregnancy-related complications.
Generated 4/1/25, 5:11 AM