Project Grant R01GM165736
- The National Institute of General Medical Sciences awarded the University of Arkansas for Medical Sciences $420,750 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research revealing DNA polymerase molecular strategies in end-joining double strand break repair. The project integrates structural biology, mechanistic biochemistry, biophysics, computational methods, and molecular biology to uncover how DNA polymerases and nucleases process and...
- The National Science Foundation (NSF) awarded a $1,100,000 Project Grant (CFDA 47.074 - Biological Sciences) to the University of Arkansas for Medical Sciences (UAMS) to study the replication of G-quadruplex DNA by translesion polymerases. This project aims to determine how proteins are recruited to sites of DNA replication and function together to copy G-quadruplex DNA structures, which can act as barriers to accurate genome replication. The research will elucidate the molecular mechanisms...
- The National Institute of General Medical Sciences awarded the University of Florida $114,100 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support basic research on the functional dynamics and regulatory mechanisms of RAD3/XPD-family helicases during DNA replication stress. The research investigates how helicases are modulated by protein-protein interactions to maintain replication fork integrity when cells encounter DNA lesions and...
- The National Institute of General Medical Sciences awarded the University of Oregon $920,642 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the molecular mechanisms of DNA breathing fluctuations and their roles in the assembly, function, and control of macromolecular complexes that direct DNA replication in bacteriophage T4. The award funds research conducted by the collaborative groups of Professors Andrew H. Marcus and Peter...
- The National Institute of General Medical Sciences awarded $315,000 to Baylor University on July 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant R01GM165898) to investigate the structural biology and mechanism of MCM8/9 helicase complex function in DNA replication fork stabilization and remodeling. The research focuses on elucidating how the MCM8/9 heterohexameric complex activates, achieves specificity in substrate recognition, and remodels...
- The National Institute of General Medical Sciences awarded the University of Arkansas $401,254 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a five-year project investigating the genetic basis of post-transcriptional regulation of cellular stress defenses. The project applies quantitative and high-throughput genetic approaches using budding yeast (Saccharomyces cerevisiae) to understand how natural genetic variation influences the...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $1.34 million on September 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of histone octamer transfer activity in BAF chromatin remodeling complexes and their relationship to cancer formation and neurodevelopmental disorders. The research examines the ARID1A subunit of CBAF complexes, which is mutated in over 20...
- The National Institute of General Medical Sciences awarded The University of Texas Health Science Center at San Antonio $433,125 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research into the spatiotemporal regulation of DNA metabolism pathways. The project examines how homologous recombination proteins are selectively activated and deactivated at DNA lesions and replication fork structures, with particular focus on tyrosine...
- The National Institute of General Medical Sciences awarded the University of Florida $386,985 on July 23, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct a five-year investigation into the structure-function relationships of single-stranded DNA (ssDNA) in biological systems. The research will develop methods to probe structured ssDNA in cells, with initial focus on two biomedically relevant lines of investigation. The first examines complex ssDNA...
- The National Institute of General Medical Sciences awarded the University of Virginia $444,125 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the mechanisms of genome integrity maintenance and break-induced replication at repetitive DNA sequences. The research focuses on elucidating how break-induced replication drives genome instability in repetitive DNA regions, particularly telomere maintenance through the alternative lengthening...
The National Institute of General Medical Sciences awarded the University of Arkansas for Medical Sciences $1,455,158 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for Project Grant R01GM165736, titled "DNA Helicases: Mechanisms and Regulation." The award funds research into the mechanisms and regulation of DNA helicases—molecular motors critical to nucleic acid processing. Mutations in helicases are associated with genomic instability, cancer predisposition, premature aging, and neurological disorders. The project focuses on understanding how helicase activity is modulated through multiprotein complex formation, phosphorylation signaling, and protein-protein interactions to maintain genome integrity during DNA replication and repair. The research centers on HELB, a DNA helicase in jawed vertebrates that promotes DNA replication initiation and inhibits homologous recombination repair of double-strand breaks, both tightly regulated processes. The University of Arkansas for Medical Sciences' Research and Sponsored Programs Division, based in Little Rock, Arkansas, is the recipient. The period of performance runs from September 1, 2026, through August 31, 2030. Work is performed in Little Rock, AR 72205.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 8/3/26 |