Project Grant R01GM165898
- Federal Project Grant Award Summary Baylor College of Medicine received a $516,608 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. The award supports fundamental research on the mechanisms and regulation of DNA recombination, with a focus on understanding how double-strand breaks (DSBs) are repaired through homologous recombination and...
- Federal Project Grant Award Summary Award Details: Baylor College of Medicine received a $440,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded February 13, 2026, with a completion date of December 31, 2030. The award supports fundamental biomedical research investigating the physical principles governing cellular condensates, particularly nucleoli and their role in ribosome...
- Federal Project Grant Award Summary Baylor University received a $562,499 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through August 31, 2028. The grant supports fundamental research investigating CTCF (CCCTC-binding factor)-mediated regulation of partial epithelial-mesenchymal transition (EMT) states. The research addresses the reversibility and...
- Federal Grant Award Summary Baylor College of Medicine received a $1.92 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded June 1, 2026, with a completion date of May 31, 2030. The award funds development of advanced technologies to detect and annotate genomic features currently hidden within intergenic regions of prokaryotic genomes. The project addresses significant gaps in...
- Federal Project Grant Award Summary The University of Texas Health Science Center at San Antonio received a $433,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded June 1, 2026, with completion targeted for January 31, 2031. The award funds research investigating the spatiotemporal regulation of DNA metabolism pathways, specifically examining how homologous recombination (HR)...
- Federal Grant Award Summary Baylor College of Medicine received a $562,817 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 1, 2026. The award funds the purchase and installation of a BD FACSDiscoverTM S8 Spectral and Imaging Cell Sorter for the institution's Cytometry and Cell Sorting Core. This instrument will support research conducted by eighteen...
- Federal Grant Award Summary Baylor College of Medicine received a $1.44 million Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025, through August 31, 2028. The award supports the development of novel classes of small, cell-permeable genome regulators based on pyrrole-imidazole polyamides—synthetic DNA-binding ligands designed to target specific genomic sequences, including...
- Federal Project Grant Award Summary The University of Virginia received a $444,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through February 28, 2031, to conduct investigator-initiated research on mechanisms of genome integrity maintenance with focus on break-induced replication (BIR) at repetitive DNA sequences. The research will elucidate how BIR drives genome...
- Federal Grant Award Summary The University of California, Davis received a $125,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through July 31, 2027. This award funds fundamental research investigating the role of mismatch repair proteins MSH2 and MSH6 in maintaining genome stability and preventing erroneous homologous recombination. The research employs...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $125,000 to Harvard Medical School under the Biomedical Research and Research Training program (CFDA 93.859) on March 1, 2026, with a completion date of February 29, 2028. This Project Grant funds fundamental research investigating the molecular mechanisms underlying transcription-replication conflicts—collisions between the cell's transcription and DNA replication machinery that destabilize...
Baylor University received a $315,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 13, 2026, with a completion date of March 31, 2030. The grant supports fundamental research investigating the mechanisms of MCM8/9 (minichromosome maintenance proteins 8 and 9) helicase complex activation, specificity, and stalled DNA replication fork remodeling. The research aims to elucidate how MCM8/9 intersects the Fanconi anemia protein fork stabilization pathway through direct interactions with FANCD2 and other associated proteins to facilitate RAD51 deposition and stabilize stalled replication forks. The project will deliver structural and functional characterization of the MCM8/9/HROB (Helicase and RPA-binding OB-fold) complex through cryo-electron microscopy (cryo-EM) structures and biochemical analysis to establish structure-function relationships for MCM8/9. This research addresses defects in mitotic and meiotic DNA replication and recombination linked to genetic diseases, cancer susceptibility, cellular aging, intellectual disabilities, and infertility, contributing to the NIGMS mission of advancing fundamental biological understanding that lays the foundation for disease diagnosis and treatment innovation.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $315.0k | 7/10/26 |