Project Grant R35GM161393
- The National Institute of General Medical Sciences awarded Louisiana State University Health Sciences Center-Shreveport $516,250 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate genome architecture and gene control in response to stress. The research examines dynamic three-dimensional rearrangements of genome topology during the heat shock response in budding yeast, with focus on how heat shock factor 1 (HSF1) drives concerted structural...
- The National Institute of General Medical Sciences awarded Oakland University $565,800 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate transcriptional regulation and chromatin structure dynamics during cellular recovery from stress, with focus on autophagy-related gene expression in yeast models. The project examines how cells maintain chromatin integrity and recover from prolonged starvation stress, specifically investigating the...
- Federal Project Grant Award Summary The University of Arkansas received a $562,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2028. This award supports fundamental research investigating lysine aminoacylation, an emerging post-translational protein modification observed in human metabolic enzymes. The project will advance understanding of...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $246,263 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into post-transcriptional regulatory networks and the integrated stress response (ISR). The work will comprehensively characterize the cofactors engaged by regulatory RNA-binding proteins and...
- The National Institute of General Medical Sciences awarded Rutgers, The State University of New Jersey, Newark Division $431,750 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular determinants of physiological stress granule homeostasis and function. The research examines stress granules—cytoplasmic structures cells form to store non-translating messenger RNAs during stress—with emphasis on axonal stress granules in peripheral...
- The National Institute of General Medical Sciences awarded the University of Connecticut Health Center $457,875 on February 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of translational response to stress, specifically how organisms regulate errors during mRNA translation to resist and acclimate to cellular stresses. The research focuses on two families of translation factors: tryptophanyl-tRNA synthetase (TrpRS) and aminoacyl-tRNA...
- The National Institute of General Medical Sciences awarded the University of Florida $383,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct basic research on post-translational modification systems in archaea, with performance through January 31, 2031, at Gainesville, Florida. The project advances understanding of how post-translational modifications coordinate to regulate stress response in the archaeon Haloferax volcanii. Three...
- The National Institute of General Medical Sciences awarded the University of Arkansas for Medical Sciences $420,750 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research revealing DNA polymerase molecular strategies in end-joining double strand break repair. The project integrates structural biology, mechanistic biochemistry, biophysics, computational methods, and molecular biology to uncover how DNA polymerases and nucleases process and...
- The National Institute of General Medical Sciences awarded The University of Iowa $393,275 on September 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to study the evolution of stress response gene regulatory networks in commensal and opportunistic yeast pathogens, with performance through August 31, 2031, at Iowa City, Iowa. The research investigates how signaling and transcriptional circuits evolve at genetic and molecular levels, using genetically related...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $444,907 on May 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on systems-level principles and mechanisms underlying cellular adaptation. The funded work investigates how cells achieve adaptive gene-expression states during short-term physiological adaptation and long-term adaptive evolution, with three primary research...
The National Institute of General Medical Sciences awarded the University of Arkansas $401,254 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a five-year project investigating the genetic basis of post-transcriptional regulation of cellular stress defenses. The project applies quantitative and high-throughput genetic approaches using budding yeast (Saccharomyces cerevisiae) to understand how natural genetic variation influences the post-transcriptional response to environmental stress and contributes to individual differences in stress susceptibility or resilience. Specific research activities include linkage mapping to identify genetic bases of natural variation in post-transcriptional stress responses, exploration of genetic architecture underlying lysine acetylation patterns during heat shock, allele swap experiments to test causal effects of identified variants, and characterization of allelic effects on fitness during stress conditions. The work addresses defects in stress defense mechanisms implicated in cancer and neurodegenerative disease, as well as post-transcriptional regulatory variation linked to human disorders. Performance occurs at the University of Arkansas, Fayetteville campus. The award period runs through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $401.3k | 7/30/26 |