The National Science Foundation (NSF) awarded a $1,100,000 Project Grant (CFDA 47.074 - Biological Sciences) to the University of Arkansas for Medical Sciences (UAMS) to study the replication of G-quadruplex DNA by translesion polymerases. This project aims to determine how proteins are recruited to sites of DNA replication and function together to copy G-quadruplex DNA structures, which can act as barriers to accurate genome replication. The research will elucidate the molecular mechanisms underlying the evolutionary selection of the REV1 translesion synthesis enzyme for promoting the successful resolution of G-quadruplex motifs. The project will also support the scientific training of high school, undergraduate, and graduate students, with a focus on broadening participation from underrepresented groups in the sciences. Additionally, UAMS has provided a $234,125 sub-grant to Hendrix College to contribute to this research on G-quadruplex DNA replication.
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